龙血竭黄酮类成分研究  

Study on Flavonoids in Resina Draconis

作　　者：张兴锋 朱功俊 龚韦凡 刘向明[1,2] 桂鹏 ZHANG Xing-feng;ZHU Gong-jun;GONG Wei-fan;LIU Xiang-ming;GUI Peng(College of Pharmacy,South-Central University for Nationalities,Hubei Wuhan 430074;GongQing Institute of Science and Technology,Jiangxi Gongqingcheng 332020,China)

机构地区：[1]中南民族大学药学院,湖北武汉430074 [2]共青科技职业学院,江西共青城332020

出　　处：《广州化工》2020年第9期92-95,共4页GuangZhou Chemical Industry

摘　　要：为了解龙血竭中主成分(黄酮类化合物)的化学组成,通过碱溶酸沉初步提取,聚酰胺柱层析、硅胶柱层析和高效液相色谱对龙血竭进一步分离,借助波谱分析手段对分离出的化合物结构进行鉴定。共分离得11个黄酮类成分,其结构分别为:7-羟基黄酮(1),5,7,4-三羟基-8-甲基黄酮(2),5,7,4-三羟基黄酮(3),2,4-二羟基-4,6-二甲氧基二氢查尔酮(4),2,4,4-三羟基-6-甲氧基二氢查尔酮(5),4,4-二羟基-2-甲氧基二氢查尔酮(6),4-羟基-2,4-二甲氧基二氢查尔酮(7),7-羟基-4-甲氧基黄烷(8),7,4-二羟基-5-甲氧基高异黄烷(9),7,4-二羟基-6-甲氧基高异黄烷(10),7,4-二羟基高异黄烷(11)。The flavonoids were extracted roughly by the method of alkali-soluble acid precipitation,and then polyamide column chromatography,silica gel column chromatography and high-performance liquid chromatography were used to further separate it.The structure of the separated compounds was identified based on spectral analysis method for understanding the chemical composition of the main components(flavonoids)in Resina draconis.A total of 11 flavonoids were separated and their structures were:7-hydroxyflavonoids(1),5,7,4’-trihydroxy-8-methylflavonoids(2),5,7,4’-trihydroxyflavonoids(3),2,4’-dihydroxy-4,6-dimethoxydihydrochal-cone(4),2,4,4’-trihydroxy-6-methoxydihydrochalcone(5),4,4’-dihydroxy-2-methoxydihydroc-halcone(6),4-hydroxy-2,4’-dimethoxydihydrochalcone(7),4’-methoxy-7-methoxyflavane(8),7,4’-dihydroxy-5-methoxyhomoisoflavane(9),7,4’-dihydroxy-6-methoxyhomoisoflavane(10),7,4’-dihydroxyhomoisoflavane(11).

关 键 词：龙血竭 黄酮 二氢查尔酮 黄烷 高异黄烷 

分 类 号：R284[医药卫生—中药学]