狼毒大戟化学成分研究  

Chemical constituents of Euphorbia fischeriana

作　　者：史影雪 赫军[2] 张佳 郭林波 高洪敏 李栋[2] 张维库[2] 续洁琨 SHI Ying-xue;HE Jun;ZHANG Jia;GUO Lin-bo;GAO Hong-min;LI Dong;ZHANG Wei-ku;XU Jie-kun(School of Life Sciences&Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Clinical Medical Sciences&Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China;Institute of Traditional Medicine and Natural Products,College of Pharmacy,Jinan University,Guangzhou 510632,China)

机构地区：[1]北京中医药大学生命科学学院&中药学院,北京100029 [2]中日友好医院临床医学研究所&药学部,北京100029 [3]暨南大学中药及天然药物研究所,广东广州510632

出　　处：《中草药》2020年第8期2107-2111,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81872761);北京市科委G20工程医药产业创新研发项目(Z181100002218029);中国医学科学院中央高校基本科研业务费项目(3332019117);新疆生产建设兵团塔里木盆地生物资源保护利用重点实验室开放课题(BRZD1704)。

摘　　要：目的研究狼毒大戟Euphorbiafischeriana根部的化学成分。方法采用硅胶、ODS、SephadexLH-20以及制备HPLC等方法进行分离纯化,根据理化性质及核磁共振波谱数据鉴定化合物的结构。结果从狼毒大戟95%乙醇提取物中分离得到14个化合物,分别鉴定为秦皮素(1)、莨菪亭(2)、反式-3-(3-羟基苯基)-丙烯酸(3)、阿魏酸(4)、和厚朴新酚(5)、3,3′-二甲基鞣花酸(6)、(3R,4S)-3-methyl-3,4-dihydro-5,6,7-trihydroxy-4-(3′-methoxy-4′-hydroxyphenyl)-1H-[2]-benzopyran-1-one(7)、异落叶松树脂醇-9-O-β-D-吡喃葡萄糖(8)、吲哚-3-甲醛(9)、苯基-β-萘胺(10)、4-epi-15-hydroxyacorenone(11)、巴卡亭(12)、24-methylenecycloartane-3,28-diol(13)和β-谷甾醇(14)。结论化合物3、5、7~11为首次从大戟属植物中分离得到,化合物1、4、6、12为首次从该植物中分离得到。Objective To investigate the chemical constitutes from the roots of Euphorbia fischeriana.Methods Compounds were isolated and purified by a combination of various chromatographic techniques including silica gel,ODS,Sephadex LH-20 gel,and preparative HPLC methods.Their structures were elucidated by physiochemical property and NMR analysis.Results Fourteen compounds were obtained from 95%ethanol extract of the roots of E.fischeriana and identified as fraxidin(1),scopoletin(2),trans-3-hydroxycinnamoyl acid(3),(E)-ferulic acid(4),obovatol(5),3,3′-di-O-methylellagic acid(6),(3 R,4 S)-3-methyl-3,4-dihydro-5,6,7-trihydroxy-4-(3′-methoxy-4′-hydroxyphenyl)-1 H-[2]-benzopyran-1-one(7),iso-lariciresinol-9-O-β-D-glucopyranoside(8),indole-3-aldehyde(9),phenyl-β-naphthylamine(10),4-epi-15-hydroxyacorenone(11),baccatin(12),24-methylenecycloartane-3,28-diol(13),andβ-sitosterol(14),respectively.Conclusion Compounds 3,5,7-11 are isolated from the genus Euphorbia for the first time.Compounds 1,4,6,12 are isolated from E.fischeriana for the first time.

关 键 词：狼毒大戟 秦皮素 和厚朴新酚 3 3′-二甲基鞣花酸 异落叶松树脂醇-9-O-β-D-吡喃葡萄糖 吲哚-3-甲醛 苯基-β-萘胺 

分 类 号：R284.1[医药卫生—中药学]