珠芽景天的化学成分研究(Ⅱ)  

Chemical constituents of Sedum bulbiferum(Ⅱ)

作　　者：马雪[1] 吴莹莹 刘理燕 姚成芬 刘亭[2] 李林珍 李勇军[1] MA Xue;WU Ying-ying;LIU Li-yan;YAO Cheng-fen;LIU Ting;LI Lin-zhen;LI Yong-jun(Engineering Research Center for the Development and Application of Ethnic Medicine and TCM(Ministry of Education),State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550004,China;Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang 550004,China;School of Pharmacy,Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学民族药与中药开发应用教育部工程研究中心/省部共建药用植物功效与利用国家重点实验室,贵州贵阳550004 [2]贵州医科大学贵州省药物制剂重点实验室,贵州贵阳550004 [3]贵州医科大学药学院,贵州贵阳550004

出　　处：《中草药》2020年第8期2112-2116,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(U1812403);贵州省创新人才团队项目(20165613/5677);中央引导地方科技专项项目(20184006)。

摘　　要：目的研究珠芽景天Sedum bulbiferum全草的化学成分。方法综合运用D101大孔树脂柱色谱、反复硅胶柱色谱、SephadexLH-20凝胶柱色谱等色谱技术进行分离,并运用MS、NMR技术对分离得到的化合物进行结构鉴定。结果从珠芽景天全草70%乙醇提取物中分离得到13个化合物,分别鉴定为4-羟基-3-甲氧基苯基-β-D-吡喃葡萄糖苷(1)、丁香酸葡萄糖苷(2)、2-(3,4-二甲氧基苯基)甲基-β-D-葡萄糖苷(3)、橄榄树脂素(4)、环橄榄树脂素-9-O-β-D-吡喃葡萄糖苷(5)、(-)-橄榄树脂素9′-O-β-D-吡喃葡萄糖苷(6)、(-)-二氢去氢二松柏醇-9-O-β-D-吡喃葡萄糖苷(7)、bluemenol A(8)、euodionoside D(9)、脑苷酯B(10)、腺苷(11)、尿苷(12)、4-(β-D-glucopyranosyloxy)-3-hydroxy-2-(hydroxymethyl)-butanenitrile(13)。结论所有化合物均首次从珠芽景天中分离得到,其中化合物1~5,8~13为首次从景天属植物中分离得到。Objective To study the chemical constituents of Sedum bulbiferum. Methods The compounds were isolated and purified by a variety of chromatographic techniques, including D-101 macroporous adsorptive resins, silica gel, Sephadex LH-20, and other methods. Their structures were identified by the MS, NMR. Results A total of 13 compounds were isolated and identified from 70% ethanol fraction of the plant, which were 4-hydroxy-3-methoxyphenyl-β-D-glucopyranoside(1), glucosyringic acid(2), 2-(3,4-methoxyphenyl)-methyl-β-D-glucopyranoside(3), olivil(4), cycloolivil-9-O-β-D-glucopyranoside(5),(-)-olivil-9′-O-β-Dglucopyranoside(6),(-)-dihydrodehydrodiconiferylalcohol 9-O-β-D-glucopyranoside(7), bluemenol A(8), euodionoside D(9), cerebroside B(10), adenosine(11), uridine(12), 4-(β-D-glucopyranosyloxy)-3-hydroxy-2-(hydroxylmethyl)-butanenitrile(13). Conclusion All compounds are isolated from S. bulbiferum for the first time. Compounds 1-5, and 8-13 are obtained from the genus Sedum for the first time.

关 键 词：珠芽景天 4-羟基-3-甲氧基苯基-β-D-吡喃葡萄糖苷 2-(3 4-二甲氧基苯基)甲基-β-D-葡萄糖苷 bluemenol A 4-(β-D-glucopyranosyloxy)-3-hydroxy-2-(hydroxymethyl)-butanenitrile 

分 类 号：R284.1[医药卫生—中药学]