仙茅的化学成分和药理活性研究进展  

Research progress on chemical constituents and pharmacological activities of Curculigo orchioides

作　　者：周芳[1,5] 姚萌[1,2] 吴倩 王思成 王炜 刘昌孝[4] 李斌[1,2] 彭彩云[1,2] ZHOU Fang;YAO Meng;WU Qian;WANG Si-cheng;WANG Wei;LIU Chang-xiao;LI Bin;PENG Cai-yun(Sino-Pakistan TCM&Ethnomedicine International Cooperation Base,Hunan University of Chinese Medicine,Changsha 410208,China;Institute of Innovative Materia Medica Research,Hunan University of Chinese Medicine,Changsha 410208,China;Chukochen Honors College,Zhejiang University,Hangzhou 310012,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China;The First affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学中巴中医药民族医药国际合作基地,湖南长沙410208 [2]湖南中医药大学创新药物研究所,湖南长沙410208 [3]浙江大学竺可桢学院,浙江杭州310012 [4]天津药物研究院,天津300301 [5]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中草药》2020年第8期2238-2247,共10页Chinese Traditional and Herbal Drugs

基　　金：湖南省“国内一流”培育学科(药学)(2018)。

摘　　要：仙茅是石蒜科多年生草本植物,民间用药历史悠久。仙茅的主要活性成分包括酚类及酚苷类、皂苷元及皂苷类、木脂素类、黄酮类、生物碱、脂肪族类等。仙茅具有消散痈肿、强筋骨、驱寒湿、补肾阳、益精血等功效,现代药理研究表明仙茅具有抗氧化、免疫调节、抗骨质疏松、补肾壮阳、肝保护、神经保护等活性。综述了仙茅的化学成分和药理活性及质量标志物的研究进展,为仙茅的进一步开发和利用提供研究依据。Curculigo orchioides is a perennial herb of Amaryllidaceae,which has a long history of folk medicine in China.The main compounds of C.orchioides include phenols and phenolic glycosides,sapogenins and saponins,lignans,flavones,alkaloids,aliphatic compounds and other type of compounds.It reported that it has the effects of dissipating carbuncle,strengthening muscles and bones,dispelling cold and dampness,tonifying kidney yang,benefiting essence and blood and so on.Modern pharmacological studies showed that C.orchioides has antioxidant,immunoregulation,kidney yang-tonifying,hepatoprotective and neuroprotective activities.This review systematically summarizes the chemical constituents,biological activities and quality marker(Q-markers)of the plant to provide a theoretical basis for further research and utilization of C.orchioides.

关 键 词：仙茅 石蒜科 酚类 酚苷 皂苷 皂苷元 木脂素 黄酮 生物碱 质量标志物 抗氧 免疫调节 

分 类 号：R285[医药卫生—中药学]