氢键活化的硝基烯参与的多组分不对称串联合成研究进展  

Advances in Multicomponent Asymmetric Cascade Synthesis Involving Hydrogen-Bond-Activated Nitroolefins

作　　者：严丽君 闫玉鑫[1] 陈雪冰[2] 王永超[1] Yan Lijun;Yan Yuxin;Chen Xuebing;Wang Yongchao(College of Vocational and Technical Education,Yunnan Normal University,Kunming 650092;School of Science,Honghe University,Mengzi,Yunnan 6611992)

机构地区：[1]云南师范大学职业技术教育学院,昆明650092 [2]红河学院理学院,云南蒙自661199

出　　处：《有机化学》2020年第4期856-872,共17页Chinese Journal of Organic Chemistry

基　　金：云南省科技厅应用基础研究(Nos.2018FD016,2017FD073,2017FD156)资助项目。

摘　　要：有机催化多组分不对称串联反应是构建复杂手性化合物的最有效方法之一,双功能手性催化剂是一类重要的单分子双活化有机小分子催化剂,能同时对多个反应底物进行氢键活化,实现多个新键的形成和多个手性中心的立体选择性控制.基于双功能催化剂氢键活化的硝基烯是一类重要的有机反应合成子,能参与多种有机小分子催化的串联反应.对硝基烯参与的多组分不对称串联反应,根据双功能催化剂的结构特征,从双功能硫脲-胺催化、双功能方酰胺-胺催化、其它双功能催化剂催化三个方面进行文献综述.从反应类型、反应机理、反应特点及应用等方面进行了系统地阐述,并对该领域的研究应用和发展前景进行了展望.Organocatalytic multicomponent asymmetric cascade reaction is generally regarded as one of the most effective methods for constructing complex chiral compounds.Bifunctional chiral catalysts are an important class of single-molecule double-activated organic catalysts,which can simultaneously activate hydrogen bonds of multiple reactive substrates to achieve the formation of multiple new bonds and stereoselective control of multiple chiral centers.Nitroolefins are important organic reaction synthons,which can participate in a variety of asymmetric cascade reactions by hydrogen bond activation.In this paper,the recent advances in nitroolefins-involved multicomponent asymmetric cascade reactions catalyzed by bifunctional organocatalysts involving chiral bifunctional thiourea amines,squaramide amines and other bifunctional catalysts are reviewed.Specifically,the catalytic systems,characteristics,mechanisms are systematically expounded,and the application of this research field is also prospected.

关 键 词：双功能催化剂 氢键活化 硝基烯 多组分反应 不对称合成 串联反应 

分 类 号：O621.251[理学—有机化学]