过氧化物诱导自由基串联环化合成苯并咪唑并异喹啉酮反应  

Peroxide-Induced Radical Relay Carbocyclization towards Polycyclic Benzimidazole[2,1-a]isoquinolines

作　　者：王薪 李国锋 孙凯[2] 张冰[1,2] WangXin;Li Guofeng;Sun Kai;Zhang Bing(School of Chemical Engineering,Zhengzhou University,Zhengzhou 450001;College of Chemistry and Chemical Engineering,Anyang Normal University,Anyang 455000;School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007)

机构地区：[1]郑州大学化工学院,郑州455001 [2]安阳师范学院化学化工学院,河南安阳455000 [3]河南师范大学化学化工学院,河南新乡453007

出　　处：《有机化学》2020年第4期913-921,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21801007);河南省高校科技创新团队(Nos.18IRTSTHN004,18HASTIT006)资助项目.

摘　　要：发展了一种过氧化物诱导的2-芳基苯并咪唑衍生物,在温和条件下经历自由基环化反应,一步合成了系列骨架多样性的苯并咪唑并异喹啉酮化合物的新方法.该反应具有底物范围宽泛、官能团兼容性好、步骤经济等特点.机理研究表明该反应经历了碳中心自由基历程.In this paper,a new peroxide-induced carbon-centered radical relay carbocyclization reaction with 2-arylbenzoimidazoles is described.This method provides an efficient route to a series of structurally diverse benzimidazole[2,1-a]isoquinolines under mild conditions in a straightforward manner.The reaction is compatible with a wide substrate scope,excellent functional group tolerance and high step economy.Mechanistic studies suggest that the reaction proceeds through a carbon-centered radical pathway.

关 键 词：自由基 碳环化 多环化合物 咪唑并异喹啉酮 

分 类 号：O626[理学—有机化学] O621.256.9[理学—化学]