Indan-f-amphox:可用于铱催化β-芳基β-酮酸酯不对称加氢反应的PNN配体  

Indan-f-amphox:An Efficient PNN Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of β-Aryl β-Ketoesters

作　　者：古国贤 胡杨 刘绍东 董秀琴[2] 张绪穆 Gu Guoxian;Hu Yang;Liu Shaodong;Dong Xiu-Qin;Zhang Xumu(School of Chemical Engineering and Technology,Tianjin Key Laboratory of Chemical Process Safety,Hebei University of Technology,Tianjin 300130,China;College of Chemistry and Molecular Science,Wuhan University,Wuhan 430072,China;Department of Chemistry,Rutgers,The State University of New Jersey,Piscataway,NJ,08854,USA;Department of Chemistry,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China)

机构地区：[1]河北工业大学化工学院,天津市本质安全化工技术重点实验室,天津300130 [2]武汉大学化学与分子科学学院,武汉430072 [3]美国新泽西州立大学罗格斯分校化学系,美国新泽西州皮斯卡塔维08854 [4]南方科技大学化学系,广东深圳518055

出　　处：《有机化学》2020年第4期997-1002,共6页Chinese Journal of Organic Chemistry

基　　金：深圳市科创委自由探索基金(No.JCYJ20170817104853520)资助项目.

摘　　要：从Ug’s胺出发通过4步化学反应合成了一种新的手性PNN三齿配体indan-f-amphox(该配体为f-amphox的姊妹配体),并将其用于铱催化的β-芳基β-酮酸酯的不对称氢化反应,结果显示Ir(Ⅲ)-indan-f-amphox催化剂对该类反应具有非常高的反应活性和立体选择性(对应选择性最高99%,转化数高达10000),适用于多种β-芳基β-酮酸酯.A new chiral tridentate PNN ligand, indan-f-amphox(a sister ligand of f-amphox), was synthesized and applied in iridium-catalyzed asymmetric hydrogenation of β-aryl β-ketoesters. A wide range of β-aryl β-ketoesters are reduced using an Ir(III)-indan-f-amphox catalyst with excellent enantioselectivities and reactivities(up to 99% ee, TON=10000).

关 键 词：PNN配体 不对称氢化 Β-酮酸酯 f-amphox 

分 类 号：O621.251[理学—有机化学]