一种新的1,3,4-噻二嗪类化合物的合成方法  

A New Method for the Synthesis of 1,3,4-Thiadiazine Derivatives

作　　者：曹雪丽 郭晓 Cao Xueli;Guo Xiao(College of Chemistry and Chemical Engineering,Taishan University,Taian,Shandong 271000;Jewim Pharmaceutical(Shandong)Co.,Ltd,Taian,Shandong 271000)

机构地区：[1]泰山学院化学化工学院,山东泰安271000 [2]山东京卫制药有限公司,山东泰安271000

出　　处：《有机化学》2020年第4期1050-1054,共5页Chinese Journal of Organic Chemistry

基　　金：泰山学院引进人才科研启动基金(No.5002353)资助项目.

摘　　要：报道了一种高效合成1,3,4-噻二嗪类化合物的新方法.以含不同取代基的α-氯代腙和2,5-二羟基-1,4-二噻烷为原料,合成了13个化合物,除(E)-4-苯基-2-苯乙烯-5,6-二氢-4H-1,3,4-噻二嗪-5-醇(3m)外,其余化合物收率均在82%以上.此外,对反应可能的机理进行了探讨.该方法操作简单,反应条件温和,对环境友好,产率高,并且底物普适性好,为1,3,4-噻二嗪类化合物的合成提供了一种新途径.An efficient method for the preparation of 1,3,4-thiadiazine derivatives has been reported.With 2,5-dihydroxy-1,4-dithiane andα-chloroindole containing different substituents,13 compounds were synthesized.The yields of the compounds were above 82%except(E)-4-phenyl-2-styryl-5,6-dihydro-4H-1,3,4-thiadiazin-5-ol(3m).Furthermore,the proposed reaction mechanism was discussed.The developed method features simple operation,mild reaction condition,environmentally friendly,high yield and a broad range of substrate applicability.It provides a new way for the synthesis of 1,3,4-thiadiazine derivatives.

关 键 词：α-氯代腙 1 3 4-噻二嗪 合成 

分 类 号：O626[理学—有机化学]