生物活性玻璃在骨修复中的应用和研究现状  

Application and research status of bioactive glass in bone repair

作　　者：黄勇华 李理[1] 石展英[1] 崔旭[2] 潘浩波[2] 李兵[1] HUANG Yonghua;LI Li;SHI Zhanying;CUI Xu;PAN Haobo;LI Bing(Department of Orthopedics,the Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou Worker’s Hospital,Liuzhou Guangxi,545005,P.R.China;Center for Human Tissues and Organs Degeneration,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen Guangdong,518055,P.R.China)

机构地区：[1]广西医科大学第四附属医院柳州市工人医院骨科,广西柳州545005 [2]中国科学院深圳先进技术研究院人体组织与器官退行性研究中心,广东深圳518055

出　　处：《中国修复重建外科杂志》2020年第5期660-666,共7页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81860385、51802340);柳州市科技重大专项资助项目(2018AF10504);广西重点研发计划资助项目(桂科AB17129001);柳州市重点研发计划资助项目(2017BH20308);深圳市大鹏新区产业发展专项资金扶持项目(KY20160108)。

摘　　要：目的综述生物活性玻璃(bioactive glass,BAG)在骨修复中的应用及研究现状。方法查阅国内外相关文献,对BAG在骨修复中的应用和研究现状进行总结。结果BAG已广泛应用于临床骨修复并取得了良好疗效。在基础研究方面,根据不同的临床应用需要,BAG以不同形态,如颗粒、假体涂层、药物及生物因子载体、骨水泥、支架等,被广泛研究应用于骨修复,并取得了显著进展。结论BAG具有良好的骨修复性能,已成为骨修复材料的研究热点,有望成为新一代骨修复材料。Objective To summarize the clinical application and research status of bioactive glass(BAG)in bone repair.Methods The recently published literature concerning BAG in bone repair at home and abroad was reviewed and summarized.Results BAG has been widely used in clinical bone repair with a favorable effectiveness.In the experimental aspect,to meet different clinical application needs,BAG has been prepared in different forms,such as particles,prosthetic coating,drug and biological factor delivery system,bone cement,and scaffold.And the significant progress has been made.Conclusion BAG has been well studied in the field of bone repair due to its excellent bone repair performance,and it is expected to become a new generation of bone repair material.

关 键 词：生物活性玻璃 骨组织工程 骨修复 研究现状 

分 类 号：R318.08[医药卫生—生物医学工程]