溶血磷脂酸对骨组织细胞生物学调控功能的研究进展  

Research progress on the biological regulatory function of lysophosphatidic acid in bone tissue cells

作　　者：吴湘楠 马媛媛 浩志超 王航[1] Wu Xiangnan;Ma Yuanyuan;Hao Zhichao;Wang Hang(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Hospital of Stomatology,Sun Yat-sen University,Guanghua School of Stomatology,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院修复科,成都610041 [2]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州510055

出　　处：《华西口腔医学杂志》2020年第3期324-329,共6页West China Journal of Stomatology

基　　金：四川省科技计划(2019YFH0153);广东省基础与应用基础研究基金(2019A1515110810)。

摘　　要：溶血磷脂酸(LPA)是一种结构简单的生物学磷脂,广泛存在于真核细胞组织和血浆中。作为胞外信号分子的LPA可以通过至少6种G蛋白偶联受体激活多条信号通路,产生广泛的细胞学效应,从而在组织发育、创伤愈合和肿瘤的发生发展中发挥重要作用。近年来研究表明,LPA对多种骨组织细胞亦表现出显著的生物学调控功能,对于骨组织的发育和修复重建具有重要影响,具备应用于骨组织工程的潜能。本文就LPA对骨组织细胞生物学调控功能的研究进展进行综述。Lysophosphatidic acid(LPA)is a small phospholipid that is present in all eukaryotic tissues and blood plasma.As an extracellular signaling molecule,LPA mediates many cellular functions by binding to six known G protein-coupled receptors and activating their downstream signaling pathways.These functions indicate that LPA may play important roles in many biological processes that include organismal development,wound healing,and carcinogenesis.Recently,many studies have found that LPA has various biological effects in different kinds of bone cells.These findings suggest that LPA is a potent regulator of bone development and remodeling and holds promising application potential in bone tissue engineering.Here,we review the recent progress on the biological regulatory function of LPA in bone tissue cells.

关 键 词：溶血磷脂酸 成骨细胞 破骨细胞 骨细胞 骨组织工程 

分 类 号：Q25[生物学—细胞生物学]