非编码RNA在人牙周膜来源细胞成骨分化中的作用  

Functions of non-coding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

作　　者：温佳慧 吴燕岷[1] 陈莉丽[1] Wen Jiahui;Wu Yanmin;Chen Lili(Dept.of Periodontology,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院牙周科,杭州310009

出　　处：《华西口腔医学杂志》2020年第3期330-337,共8页West China Journal of Stomatology

基　　金：浙江省基础公益研究计划(LGF18H140003)。

摘　　要：人牙周膜来源细胞是牙周再生的重要种子细胞,其成骨潜能密切影响牙槽骨修复和牙周再生。非编码RNA(ncRNA)积极参与调控人牙周膜来源细胞的成骨基因,其主要包括微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)等。本文就ncRNA在人牙周膜来源细胞成骨分化的调控靶点、作用通路及发挥功能的研究进展进行综述。Human periodontal ligament-derived cells serve as an important source of seeding cells in periodontal regenerative medicine,and their osteogenic potential is closely related to alveolar bone repair and periodontal regeneration.Noncoding RNA(ncRNA),such as microRNA,long non-coding RNA,and circular RNA,play important roles in the regulation of osteogenic genes in human periodontal ligament-derived cells.In this review,we summarize the target genes,pathways,and functions of the ncRNA network during osteogenic differentiation of periodontal ligament-derived cells.

关 键 词：微小RNA 长链非编码RNA 环状RNA 牙周膜细胞 牙周膜干细胞 成骨分化 

分 类 号：Q254[生物学—细胞生物学]