肾综合征出血热与HLA基因多态性相关性研究进展  

Research progress in patients of hemorrhagic fever with renal syndrome and HLA gene polymorphism

作　　者：刘淦 杨进孙[2] 孙恩涛 LIU Gan;YANG Jin-sun;SUN En-tao(School of Laboratory Medicine,Wannan Medical College,Wuhu 241002,China;Department of Infectious Diseases,Yijishan Hospital of Wannan Medical College)

机构地区：[1]皖南医学院检验学院,芜湖241002 [2]皖南医学院弋矶山医院

出　　处：《热带病与寄生虫学》2020年第2期127-131,共5页Journal of Tropical Diseases and Parasitology

基　　金：国家自然科学基金项目(31870352);皖南医学院2019年青年卓越人才资助项目(Wyqnyx201902);皖南医学院大学生科研基金项目(WK2019S19);安徽省省级大学生创新创业项目(201810368140)。

摘　　要：肾综合征出血热(Hemorrhagic fever with renal syndrome,HFRS)是源于动物感染的自然疫源性疾病,HFRS的发病机制受多因素共同调控,其中病原免疫性因素在HFRS中起主导作用。研究发现HFRS与人类白细胞抗原(Human lymphocyte antigen,HLA)基因多态性关系密切,HFRS遗传相关性及病程严重度在一定水平上受HLA基因多态性影响。本文就HFRS与HLA基因多态性的相关研究进展作综述,为临床早期筛查诊断HFRS及评估发病风险提供科学依据。Hemorrhagic fever with renal syndrome(HFRS)is a natural focus disease originated from animal infection.The pathogenesis of HFRS is controlled by many factors,in which the pathogenic immune plays a major role.Studies demonstrated that HFRS was closely connected with human leukocyte antigen(HLA)gene polymorphism,and the genetic correlation and course severity of HFRS were affected by HLA gene polymorphism at a certain level.This paper aims at reviewing the research progress in HFRS and HLA gene polymorphism in order to provide a scientific basis for early clinical screening and diagnosis of HFRS as well as assessment of the disease risks.

关 键 词：人类白细胞抗原 多态性 肾综合征出血热 相关性 进展 

分 类 号：R373.32[医药卫生—病原生物学]