贵州省少数民族地区男性人群吸烟、饮酒及乙肝感染对肝功能异常影响的现况研究  

Smoking,drinking and hepatitis B infection in male population in minority areas of Guizhou Province:a cross-sectional study

作　　者：黄瑶 黄文湧 杨敬源 汪俊华 蒋芝月[1,2,3] 官志忠 HUANG Yao;HUANG Wen-yong;YANG Jing-yuan;WANG Jun-hua;JIANG Zhi-yue;GUAN Zhi-zhong(Department of Epidemiology and Health Statistics,School of Public Health,Guizhou Medical University,Guian,Guizhou 550025,China)

机构地区：[1]贵州医科大学公共卫生学院流行病学与卫生统计学系,贵州贵安550025 [2]贵州医科大学环境污染与疾病监控教育部重点实验室,贵州贵安550025 [3]贵州医科大学贵州省卫生发展研究院,贵州贵安550025 [4]贵州医科大学贵州省医学分子生物学重点实验室,贵州贵阳550025

出　　处：《现代预防医学》2020年第9期1673-1677,1698,共6页Modern Preventive Medicine

基　　金：科技部“十二五”国家科技支撑计划(2013BAIO5B03)。

摘　　要：目的探讨贵州省少数民族地区男性人群吸烟、饮酒及乙肝感染(简称HBV感染)对肝功能异常的影响,为少数民族地区预防肝脏疾病提供科学依据。方法采用多阶段分层整群随机抽样的方法抽取贵州省少数民族自治州地区农村常住男性居民,采取问卷调查并检测其乙肝血清学指标(HbsAg和抗-Hbc)和5项肝功能指标(ALT、AST、TBIL、DBIL和IBIL)。非条件二元logistic回归分析比较吸烟、饮酒及HBV感染者的肝功能异常情况。结果 722名研究对象中,吸烟率为38.78%,饮酒率59.83%,HBV感染率为22.30%;logistic回归分析调整年龄、民族和婚姻状况后,以"不吸烟+不饮酒+HBV阴性"者为参比,"仅HBV阳性"ALT和AST异常的aOR(95%CI)为2.96(1.16,7.55)和2.39(0.84,6.79);"吸烟+饮酒"aOR(95%CI)分别为3.72(1.84,7.50)和5.00(2.38,10.47);"HBV阳性+吸烟+饮酒"aOR(95%CI)分别为5.64(2.38,13.38)和4.48(1.78,11.26)。与"不吸烟+不饮酒+HBV阴性"者相比,"任意1项阳性"、"任意2项阳性"和"全阳性"对ALT肝功能异常的aOR(95%CI)分别为3.01(1.52,2.99)、3.91(1.98,7.72)和5.55(2.34,13.16);对AST肝功能异常的aOR(95%CI)分别为2.85(1.36,5.97)、4.40(2.13,9.08)和4.49(1.79,11.27)。结论贵州省少数民族男性人群饮酒、吸烟和HBV感染均与肝功能异常存在关联,建议加强乙肝疫苗接种的同时重视生活方式,从而减少肝脏疾病的发生。Objective To explore the effects of smoking, drinking and hepatitis B(HBV) infection on liver dysfunction in male population in minority areas of Guizhou Province, and to provide scientific evidence for prevention of liver diseases among them. Methods Multi-stage stratified cluster random sampling was used to select rural resident male residents in Guizhou minority autonomous prefectures. Questionnaire survey and detection of HBV serological indicators(HbsAg and anti-Hbc) and five liver function indicators(ALT, AST, TBIL, DBIL and IBIL) were adopted, and unconditionalbinary logistic regression analysis was used to explore the effects of smoking, drinking and HBV infection on liver dysfunction. Results Total 722 subjects were included in this study, the smoking rate was 38.78%, the drinking rate was 59.83%, and the HBV infection rate was 22.30%. After adjusting age, nationality and marital status with logistic regression analysis, compared with "non-smoking, non-drinking and HBV negative", the "HBV positive only" aOR(95%CI) for ALT and AST was 2.96(1.16, 7.55) and 2.39(0.84, 6.79). "Smoking and drinking" aOR(95%CI) for ALT and AST were 3.7(1.84, 7.50) and 5.00(2.38, 10.47). "HBV positive, smoking and drinking" aOR(95%CI) for ALT and AST were 5.64(2.38, 13.38) and 4.48(1.78, 11.26), respectively. Compared with "non-smoking, non-drinking and HBV negative", "any positive", "any two positive", and "all positive" aOR(95%CI) for ALT liver dysfunction were 3.01(1.52, 2.99), 3.91(1.98, 7.72) and 5.55(2.34, 13.16), respectively. The aOR(95%CI) for AST liver dysfunction were 2.85(1.36, 5.97), 4.40(2.13, 9.08) and 4.49(1.79, 11.27). Conclusion Drinking, smoking and HBV infections among ethnic minority males in Guizhou province are associated with liver dysfunction. It is suggested that Strengthening hepatitis B vaccination while paying attention to lifestyle, especially drinking human can reduce the occurrence of liver disease in the future.

关 键 词：吸烟 饮酒 HBV感染 肝功能异常 现况研究 

分 类 号：R512.62[医药卫生—内科学]