口服和局部美沙拉嗪联用对中型远端结肠炎缓解期患者疗效的影响  

Efficacy of oral and topical mesalazine on patients with moderate distal colitis

作　　者：董时洁[1] 张征[1] DONG Shi-jie;ZHANG Zheng(Department of Gastroenterology,People's Hospital of Yixing,Yixing 214200,China)

机构地区：[1]宜兴市人民医院消化内科,江苏宜兴214200

出　　处：《中国中西医结合消化杂志》2020年第4期251-255,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]观察口服和局部美沙拉嗪联用对中型远端结肠炎缓解期患者临床疗效的影响效果。[方法]按照随机数余数分组法将2017-03-2019-03收治的80例中型远端结肠炎缓解期患者分为口服美沙拉嗪治疗的口服给药组(30例)、局部美沙拉嗪治疗的局部给药组(30例)、口服和局部美沙拉嗪联用治疗的联合给药组(20例),对3组临床疗效进行对比。[结果]治疗前3组血清炎症因子、氧化应激指标、直肠肛门动力学、黏膜损伤指数、病理组织学评分差异无统计学意义(P>0.05),治疗后均较治疗前显著改善,联合给药组优于口服给药组和局部给药组(P<0.05),口服给药组与局部给药组差异无统计学意义(P>0.05);3组总有效率分别为95.00%、83.33%、86.67%,联合给药组高于口服给药组和局部给药组(P<0.05),口服给药组与局部给药组差异无统计学意义(P>0.05);3组不良反应发生率分别为15.00%、13.33%、10.00%,差异无统计学意义(P>0.05)。[结论]口服和局部美沙拉嗪联用治疗中型远端结肠炎缓解期疗效更佳,可作为优选用药方案推广使用。[Objective]To observe the effect of oral and topical mesalazine on patients with moderate distal colitis.[Methods]According to the random number remainder grouping will be from March 2017 to March 2019 were 80 medium-sized distal colitis remission patients divided into oral beauty salad oxazine treatment of oral drug group of 30 cases,local beauty salad oxazine local drug group of 30 cases of treatment,oral and topical salad oxazine adjunctive therapy combined drug group 20 cases,were compared in three groups of clinical curative effect.[Results]There were no significant differences in serum inflammatory factors,oxidative stress index,rectal anal kinetics,mucosal injury index and histopathological scores between the three groups before treatment(P>0.05).After treatment,they were significantly improved compared with before treatment.There was a statistically significant difference between the oral administration group and the local administration group(P<0.05).There was no significant difference between the oral administration group and the local administration group(P>0.05).The total effective rate of the three groups was 95.00%,83.33%,86.67%,the combination group was higher than the oral administration group and the local administration group,and there was statistical difference(P<0.05).There was no significant difference between the oral administration group and the local administration group(P>0.05).The incidence of adverse reactions in the three groups was 15.00%,13.33%,and 10.00%,respectively,and there was no statistical difference(P>0.05).[Conclusion]The combination of oral and topical mesalazine in the treatment of moderate-term distal colitis is more effective and can be used as a preferred drug regimen.

关 键 词：中型远端结肠炎 美沙拉嗪 疗效 

分 类 号：R273[医药卫生—中西医结合]