逍遥丸及补肾抑乳汤联合溴隐亭治疗男性高泌乳血症的疗效观察  

Clinical Observation of Xiaoyao Pills and Bushen Yiru Decoction Combined with Bromocriptine for Treatment of Male Hyperprolactinemia

作　　者：锁苗 李惠林[1] 周文彬[1] 赵恒侠[1] 张学文[2] SUO Miao;LI Hui-Lin;ZHOU Wen-Bin;ZHAO Heng-Xia;ZHANG Xue-Wen(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;The First Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000 Shaanxi,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]陕西中医药大学第一附属医院,陕西咸阳712000

出　　处：《广州中医药大学学报》2020年第5期856-860,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：深圳市医疗卫生三名工程项目国医大师张学文团队基金项目(编号:SZSM201512043);李惠林广东省名老中医药专家传承工作室项目。

摘　　要：【目的】观察逍遥丸及补肾抑乳汤联合溴隐亭治疗男性高泌乳素血症(肝郁肾虚证)患者的临床疗效。【方法】将72例高泌乳素血症(肝郁肾虚证)的男性患者随机分为试验组和对照组,每组各36例。对照组给予口服甲磺酸溴隐亭片治疗,试验组在对照组的基础上加服逍遥丸和补肾抑乳汤治疗。1个月为1个疗程,共治疗3个疗程。观察2组患者治疗前后中医证候评分(阳痿、性欲下降、焦虑和腰酸痛)及性激素水平[泌乳素(PRL)、促黄体生成素(LH)、卵泡生成素(FSH)和睾酮(T)]的变化情况,并评价2组的疗效及安全性。【结果】(1)治疗3个月后,试验组的总有效率为91.67%(33/36),对照组为83.33%(30/36),试验组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的阳痿、性欲下降、焦虑和腰酸痛等各项中医证候评分均较治疗前明显改善(P<0.05),且试验组的改善作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患者的PRL水平均较治疗前降低(P<0.05),FSH、LH、T水平均较治疗前升高(P<0.05),且试验组对PRL水平的降低作用及对FSH、LH、T水平的升高作用均明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗过程中,2组患者的各项安全性指标均无明显异常变化。【结论】逍遥丸及补肾抑乳汤联合溴隐亭治疗男性高泌乳素血症疗效显著,不仅可恢复患者的各项性激素指标水平,还可有效缓解患者的性功能障碍、性欲减退、腰酸和焦虑等临床症状。Objective To observe the therapeutic effect of Xiaoyao Pills and Bushen Yiru Decoction combined with Bromocriptine for the treatment of male hyperprolactinemia patients with the syndrome of liver stagnation and kidney deficiency.Methods Seventy-two male hyperprolactinemia patients with the syndrome of liver stagnation and kidney deficiency were randomly divided into trial group and control group,and each group had 36 cases.The control group was given oral use of Bromocriptine Mesylate Tablets,and the trial group was given oral use of Xiaoyao Pills and Bushen Yiru Decoction combined with Bromocriptine Mesylate Tablets.One month constituted a course of treatment,and the treatment for the two groups lasted 3 courses.Before and after treatment,the changes in the scores of traditional Chinese medicine(TCM)syndrome manifestations such as impotence,decreased sexual desire,anxiety,and lumbar ache and pain,and the changes in the levels of sex hormones such as prolactin(PRL),luteinizing hormone(LH),follicle-stimulating hormone(FSH),and testosterone(T)were observed.After treatment,the clinical efficacy and safety of the two groups were evaluated.Results(1)After treatment for 3 months,the total effective rate of the trial group was 91.67%,and that of the control group was83.30%.The clinical efficacy of the trial group was superior to that of the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the scores of the TCM symptoms such as impotence,decreased sexual desire,anxiety,and lumbar ache and pain in the two groups were obviously improved in comparison with those before treatment(P<0.05),and the improvement in the trial group was superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment,the PRL level was decreased and the levels of FSH,LH and T were increased in the two groups as compared with those before treatment(P<0.05),and the trial group had stronger effect on decreasing PRL level and on increasing the levels of FSH,LH and T

关 键 词：逍遥丸 补肾抑乳汤 溴隐亭 男性高泌乳素血症 性激素 性功能障碍 

分 类 号：R259.881[医药卫生—中西医结合]