雷公藤多苷药理作用及肝毒性机制研究  

Study on Pharmacological Effects of Tripterygium Glycosides and Hepatotoxicity

作　　者：付晓春[1] 沈小莉[1] 蒋平[1] FU Xiao-chun;SHEN Xiao-li;JIANG Ping(Department of Pharmacology,School of Pharmacy,Guangdong Food and Drug Vocational College,Guangzhou 510520,Guangdong,China)

机构地区：[1]广东食品药品职业学院药学院药理教研室,广东广州510520

出　　处：《医学信息》2020年第5期37-39,共3页Journal of Medical Information

基　　金：广州市科技计划项目(编号:201707010012)。

摘　　要：雷公藤多苷是从中药雷公藤中提取的有效组分,主要活性成分二萜内酯类化合物具有抗炎及免疫抑制活性,因其临床疗效显著,被广泛应用于类风湿性关节炎、肾病综合征、过敏性紫癜、哮喘等疾病的治疗。但在治疗过程中,雷公藤多苷可引起肝脏损伤,其肝毒性作用主要由脂质过氧化反应、肝细胞凋亡、免疫损伤、肝药酶活性改变及代谢异常等引起。为进一步了解雷公藤多苷的肝毒性作用,本文通过对雷公藤多苷的药理作用及其肝毒性作用作一综述,旨在为临床研究雷公藤多苷提供参考。Tripterygium glycosides is an effective component extracted from the traditional Chinese medicine tripterygium wilfordii,and the main active ingredient of diterpene lactone compounds has anti-inflammatory and immunosuppressive activities.Because of its significant clinical efficacy,it is widely used in the treatment of rheumatoid arthritis,nephrotic syndrome,allergic purpura,asthma and other diseases.However,in the course of treatment,tripterygium glycosides can cause liver damage,and its hepatotoxicity is mainly caused by lipid peroxidation,hepatocyte apoptosis,immune damage,liver drug enzyme activity changes and metabolic abnormalities.In order to further understand the hepatotoxicity of triptolide,this article reviews the pharmacological effects of tripterygium glycosides and its hepatotoxicity in order to provide a reference for clinical research of tripterygium glycosides.

关 键 词：雷公藤多苷 抗炎免疫 肝脏毒性 肝毒性机制 

分 类 号：R969[医药卫生—药理学]