依帕司他片辅助治疗对糖尿病视网膜病变患者SOD、TAOC及TNF-α水平的影响  

Effects of Adjuvant Epalrestat on SOD,TAOC and TNF-αLevels in Patients with Diabetic Retinopathy

作　　者：潘浩 PAN Hao(Department of Endocrinology,Tianjin Xiqing Hospital,Tianjin 300380,China)

机构地区：[1]天津市西青医院内分泌科,天津300380

出　　处：《医学信息》2020年第5期100-101,共2页Journal of Medical Information

摘　　要：目的探究依帕司他片辅助治疗对糖尿病视网膜病变患者超氧化物歧化酶(SOD)、总抗氧化能力(TAOC)及肿瘤坏死因子-α(TNF-α)水平的影响。方法选取2018年1月~2019年5月就诊于我院的糖尿病视网膜病变患者100例,按随机数字表法分为对照组和研究组,各50例。对照组采用前列地尔治疗,研究组在对照组基础上给予依帕司他片治疗。比较两组治疗效果、治疗前后SOD、TAOC及TNF-α水平。结果研究组治疗总有效率(96.00%)高于对照组(84.00%)(P<0.05);治疗后,研究组SOD、TAOC水平高于对照组,TNF-α水平低于对照组(P<0.05)。结论依帕司他片辅助治疗糖尿病视网膜病变的疗效优于单用前列地尔,且有助于改善患者SOD、TAOC及TNF-α水平。Objective To explore the effects of adjuvant epalrestat on superoxide dismutase(SOD),total antioxidant capacity(TAOC)and tumor necrosis factor-α(TNF-α)levels in patients with diabetic retinopathy.Methods A total of 100 patients with diabetic retinopathy who were admitted to our hospital from January 2018 to May 2019 were selected and according to the random number table method,divided into a control group and a study group,with 50 cases in each group.The control group was treated with alprostadil,and the research group was given epalrestat tablets on the basis of the control group.The treatment effects,SOD,TAOC and TNF-αlevels were compared between the two groups.Results The total effective rate of treatment in the study group(96.00%)was higher than that in the control group(84.00%)(P<0.05).After treatment,the levels of SOD and TAOC in the study group were higher than those in the control group,and the levels of TNF-αwere lower than those in the control group(P<0.05).Conclusion Epalrestat tablets are more effective in the treatment of diabetic retinopathy than alprostadil alone,and can help improve the levels of SOD,TAOC and TNF-αin patients.

关 键 词：糖尿病视网膜病变 依帕司他片 SOD TAOC TNF-Α 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]