基于网络药理学分析半夏-黄芩-黄连治疗幽门螺杆菌相关性胃炎的作用机制  

Mechanism of Pinellia-Scutellaria-Coptis in treating Helicobacter pylori-related gastritis based on network pharmacology

作　　者：张彧[1] 吴东升[1] 徐寅[2] 杨仁义[1] 喻斌[2] ZHANG Yu;WU Dong-sheng;XU Yin;YANG Ren-yi;YU Bin(Hunan University of Chinese Medicine,Changsha 410208,China;First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学,长沙4102082 [2]湖南中医药大学第一附属医院,长沙410007

出　　处：《天然产物研究与开发》2020年第4期592-599,共8页Natural Product Research and Development

基　　金：国家自然科学基金青年科学基金(81904176);湖南省科技创新项目(2018SK51201);湖南省研究生科研创新项目(CX20190593);湖南中医药大学中医学国内一流建设学科(2018年-2020年)。

摘　　要：基于前期数据挖掘结果,采用网络药理学方法分析"半夏-黄芩-黄连"治疗幽门螺杆菌(Hp)相关性胃炎的主要有效化合物及作用机制。本研究通过TCMSP平台筛选"半夏-黄芩-黄连"药对中潜在活性成分;Swiss Target Prediction数据库获得潜在活性成分的作用靶点,Gene Cards数据库、OMIM数据库获得Hp相关性胃炎的主要致病靶点;构建"中药-成分-靶点"网络模型及PPI网络图分析药对中主要活性成分及作用靶点蛋白;采用David数据库对药对作用靶点进行生物功能及代谢通路分析。筛选出药对潜在活性成分35个;得到药对治疗Hp相关性胃炎的潜在作用靶点蛋白37个;涉及通路77条。该研究初步揭示了"半夏-黄芩-黄连"干预Hp感染诱导的慢性胃炎可能是通过多成分、多靶点、多途径发挥抗炎作用,并调控胃癌进程,为阐释其治疗Hp相关性胃炎的作用机制与物质基础提供了科学依据。Consulting the previous research,the paper analyzed the main effective compounds and mechanisms of Pinellia,Scutellaria and Coptis in treating Helicobacter pylori associated gastritis based on network pharmacology.The compounds of Pinellia,Scutellaria and Coptis were obtained in the TCMSP platform.The targets of compounds were obtained in the Swiss Target Prediction database.The targets of Helicobacter pylori associated gastritis were obtained in the Gene Cards database and the OMIM database.Constructed a "herbs-compounds-targets" network association diagram and protein-protein interaction to analyze the main effective compounds and targets in Pinellia,Scutellaria and Coptis.A functional enrichment analysis and metabolic pathway of the targets of Pinellia,Scutellaria and Coptis were analyzed in David database.A total of 35 potential active compounds were screened,37 targets were related to disease and 77 pathways were involved.The herapeutic mechanism of Pinellia,Scutellaria and Coptis on the Helicobacter pylori associated gastritis and regulating the gastric cancer reflects the characteristics of multi-component,multi-target,and multi-pathway,which provides a scientific basis for further explaining the action mechanism and the material basis of Pinellia,Scutellaria and Coptis against Helicobacter pylori associated gastritis.

关 键 词：幽门螺杆菌相关性胃炎 半夏 黄芩 黄连 网络药理学 

分 类 号：R285[医药卫生—中药学]