白头婆花化学成分的分离与鉴定  

Isolation and identification of chemical constituents in the flowers of Eupatorium japonicum

作　　者：田云刚[1] 郭洪伟 刘一涵[1] 王建霞[1] 田兰 李思迪 魏华[1,3] TIAN Yun-gang;GUO Hong-wei;LIU Yi-han;WANG Jian-xia;TIAN Lan;LI Si-di;WEI Hua(Collge of Biotic Resource and Enironmental Science,Jishou Unirersity;Ethnic Minority Traditional Medicine Institute of Xiangxi;Tujia Medicine Research Center in Hunan,Jishou 416000,China)

机构地区：[1]吉首大学生物资源与环境科学学院 [2]湘西自治州民族医药研究所 [3]湖南省土家医药研究中心,吉首416000

出　　处：《天然产物研究与开发》2020年第4期607-612,共6页Natural Product Research and Development

基　　金：国家自然科学基金(81960774);湖南省土家医药研究中心开放项目(TJY201901);吉首大学研究生科研创新项目(JGY201927);吉首大学森林生态系统观测研究生培养创新基地项目(JSUFI201806)。

摘　　要：本文为研究白头婆(Eupatorium japonicum)花的化学成分,利用多种色谱技术对白头婆花70%乙醇提取物进行分离得到19个化合物,经NMR、MS等波谱方法鉴定为香豆素(1)、2-hydroxy-2,6-dimethylbenzofuran-3(2H)-one(2)、1-(2-hydroxy-4-methylphenyl)propan-1,2-dione(3)、subamone(4)、(7R^*)-opposit-4(15)-ene-1β,7-diol(5)、2,5-二羟基苯甲酸(6)、咖啡酸(7)、9-羟基百里酚(8)、原儿茶酸(9)、反式邻羟基肉桂酸(10)、7-羟基香豆素(11)、槲皮素(12)、蒲公英甾醇(13)、9-acetoxythymol 3-O-tiglate(14)、蒲公英甾醇乙酸酯(15)、亚油酸(16)、9-angeloyloxythymol(17)、豆甾醇(18)、棕榈酸(19)。化合物2~9、11~13、16、19为首次从白头婆中分离得到,化合物4~6、16为首次从泽兰属中分离得到。To study chemical constituents of the flowers of Eupatorium japonicum.Nineteen known compounds were isolated from the 70% ethanol extraction of the flowers of E.japonicum by various chromatographic methods.On the basis of NMR and MS spectroscopic analysis,their structures were identified as coumarin(1),2-hydroxy-2,6-dimethylbenzofuran-3(2 H)-one(2),1-(2-hydroxy-4-methylphenyl)propan-1,2-dione(3),subamone(4),(7R^*)-opposit-4(15)-ene-1β,7-diol(5),gentisic acid(6),caffeic acid(7),9-hydroxythymol(8),protocatechuic acid(9),trans-o-hydroxycinnamic acid(10),umbelliferone(11),quercetin(12),traxasterol(13),9-acetoxythymol 3-O-tiglate(14),taraxasterol acetate(15),linoleic acid(16),9-angeloyloxythymol(17),stigmasterol(18),palmitic acid(19).Compounds 2-9,11-13,16,19 were isolated from E.japonicum for the first time,and compounds 4-6,16 were isolated from the genus of Eupatorium for the first time.

关 键 词：白头婆 化学成分 分离 鉴定 

分 类 号：R284.1[医药卫生—中药学]