蓝光光疗对新生儿黄疸的临床疗效及其对生长发育的影响  

The clinical effect of blue light therapy on neonatal jaundice and its effect on growth and development

作　　者：兰婷婷[1] 邓全敏[1] 詹璐[1] LAN Ting-ting;DENG Quan-min;ZHAN Lu(Department of Pediatrics,Deyang People's Hospital,Deyang 618000,Sichuan,China)

机构地区：[1]德阳市人民医院儿科,四川德阳618000

出　　处：《川北医学院学报》2020年第2期305-308,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨蓝光光疗对新生儿黄疸的临床疗效及其对预后影响。方法:通过随机数表法,将90例新生儿黄疸患儿分为观察组和对照组,每组各45例。对照组给予常规治疗方案,包括服抗生素、吸入氧气、纠正水电解质的平衡等,并给予茵栀黄口服液口服;观察组在常规治疗基础上联合蓝光间歇照射,每次照射3~5 h,停止2~4 h后继续照射,连续治疗4 d。比较两组患儿治疗前后血清转铁蛋白、胆红素、黄疸消退时间、生长发育情况和不良反应发生率。结果:治疗后,观察组退黄总有效率明显高于对照组(95.56%vs.82.22%,P<0.05);观察组血清转铁蛋白水平高于对照组[(1.97±0.28)g/L vs.(1.63±0.25)g/L,P<0.05];观察组胆红素水平低于对照组[(93.28±15.70)μmol/L vs.(115.74±20.08)μmol/L],消退时间短于对照组[(2.74±0.83)d vs.(4.36±1.13)d],差异有统计学意义(P<0.05)。观察组患儿体质量、身长、头围均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:蓝光光疗治疗新生儿黄疸疗效明显,有助于促进黄疸消退,改善血清转铁蛋白、胆红素的表达及预后,值得应用推广。Objective:To study the clinical effect of blue light therapy on neonatal jaundice and its effect on growth and development.Methods:90 neonatal jaundice patients were divided into observation group and control group by random number table method,45 cases in each.The control group was given routine treatment,including taking antibiotics,inhaling oxygen,correcting the balance of water and electrolyte,as well as Yinzhihuang oral liquid.The observation group was treated with blue light intermittent irradiation on the basis of routine treatment,each irradiation lasted for 3-5 hours,stopped for 2-4 hours,and then continued irradiation for 4 days.The serum transferrin,bilirubin,jaundice subsiding time,growth and development,and the incidence of adverse reactions were compared between the two groups before and after treatment.Results:After treatment,the total effective rate of jaundice regression in the observation group was significantly higher than that in the control group,the difference was statistically significant(95.56%vs.82.22%,P<0.05),the level of serum transferrin in observation group was higher than that in control group[(1.97±0.28)g/L vs.(1.63±0.25)g/L,P<0.05],the bilirubin level in the observation group was lower than that in the control group[(93.28±15.70)μmol/L vs.(115.74±20.08)μmol/L],and the regression time was shorter than that in the control group[(2.74±0.83)d vs.(4.36±1.13)d],the differences were statistically significant(P<0.05).The body weight,body length and head circumference of children in observation group were higher than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Blue light therapy has obvious therapeutic effect on neonatal jaundice,which is helpful to promote jaundice regression,improve the expression and prognosis of serum transferrin and bilirubin.It is worth popularizing.

关 键 词：新生儿黄疸 蓝光间歇照射 茵栀黄口服液 转铁蛋白 胆红素 

分 类 号：R722.1[医药卫生—儿科]