DNA高甲基化在临床常见疾病中的作用及5-氮胞苷干预的基础研究  

Role of DNA Hypermethylation in Common Clinical Diseases and Basic Research on Intervention of 5-Azacytidine

作　　者：刘佳嘉 张程 张湘燕[2] LIU Jiajia;ZHANG Cheng;ZHANG Xiangyan(Zunyi Medical University,Zunyi 563000,China;Department of Respiratory and Critical Care Medicine,Guizhou Provincial People′s Hospital,Guiyang 550002,China)

机构地区：[1]遵义医科大学,贵州遵义563000 [2]贵州省人民医院呼吸与危重症医学科,贵阳550002

出　　处：《医学综述》2020年第10期1893-1898,共6页Medical Recapitulate

基　　金：国家自然科学基金(81560012);贵阳市科技计划项目(〔20161001〕09号)。

摘　　要：DNA甲基化是真核生物基因表达调控的一种方式,是最具特征的表观遗传现象。基因高甲基化引起的基因沉默可能导致许多疾病的发生、发展。基因高甲基化参与肿瘤、自身免疫性疾病、慢性阻塞性肺疾病等临床常见疾病的发病机制并且影响预后。5-氮胞苷是不同类型癌症治疗中使用的临床化疗药物,作为最主要的DNA甲基转移酶抑制剂,5-氮胞苷强烈的去甲基作用可以实现异常沉默基因的重新表达,恢复其正常功能,在相关疾病的应用与进展中发挥着越来越重要的作用。DNA methylation is a way of gene expression regulation in eukaryotes and is the most characteristic epigenetic phenomenon.That gene silencing caused by gene hypermethylation leads to the occurrence and development of many diseases.It has been confirmed that gene hypermethylation participates in the pathogenesis of common clinical diseases such as tumors/cancer,autoimmune diseases,and chronic obstructive pulmonary diseases,and affects the prognosis.The clinical chemotherapeutic drug 5-azacytidine,as the most important demethylation agent,can induce the re-expression of abnormally silenced genes and restore their normal functions,which plays an increasingly important role in the application and progress of related diseases.

关 键 词：DNA高甲基化 5-氮胞苷 干预 基础研究 

分 类 号：R593[医药卫生—内科学]