脂联素对缺血性肾脏病保护作用的研究进展  

Research Progress in Protective Effect of Adiponectin on Ischemic Renal Disease

作　　者：郑晓彤 刘大军[1] ZHENG Xiaotong;LIU Dajun(Department of Nephrology,Shengjing Hospital,China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院肾脏内科,沈阳110000

出　　处：《医学综述》2020年第10期1904-1908,共5页Medical Recapitulate

基　　金：辽宁省自然科学基金指导计划立项项目(20170541057)。

摘　　要：脂联素是脂肪组织分泌的胶原样蛋白质,在调节能量代谢和炎症反应中发挥重要作用。脂联素具有抗动脉粥样硬化、抗炎、抗纤维化、抗细胞凋亡、促血管生成的作用,可用于糖尿病等的治疗。脂联素可以减轻心肌中炎症介质的激活以及纤维化的出现,进而对心血管疾病起到明显的保护作用。肾脏是人体的高灌注器官,对缺血非常敏感,在缺血性肾脏病中,脂联素可通过与脂质代谢的有效生物学作用发挥肾脏保护作用。Adiponectin is a collagen-like protein secreted by adipose tissue and plays an important role in regulating energy metabolism and inflammation.Adiponectin has the roles of anti-atherosclerosis,anti-inflammation,anti-fibrosis,anti-apoptosis,angiogenesis,and can be used in the treatment of diabetes.Adiponectin has been shown to reduce the activation of inflammatory mediators in the myocardium and the occurrence of fibrosis,and it has obvious protective effect on cardiovascular diseases.The kidney is a highly perfused organ of the human body and is very sensitive to ischemia.In ischemic kidney disease,adiponectin can exert renal protection through effective biological effects on lipid metabolism.

关 键 词：缺血性肾脏病 脂联素 动脉粥样硬化 炎症因子 纤维化 凋亡 

分 类 号：R692[医药卫生—泌尿科学]