Tamm-Horsfall蛋白在肾脏疾病中的研究进展  

Research Progress of Tamm-Horsfall Protein in Kidney Disease

作　　者：方道成 胡媛媛 谷江 FANG Daocheng;HU Yuanyuan;GU Jiang(Guizhou Medical University,Guiyang 550001,China;Department of Urology Surgery,the Affiliated Hospital of Guizhou Medical University,Guiyang 550001,China)

机构地区：[1]贵州医科大学,贵阳550001 [2]贵州医科大学附属医院泌尿外科,贵阳550001

出　　处：《医学综述》2020年第10期1919-1923,1929,共6页Medical Recapitulate

摘　　要：肾脏疾病是一类常见疾病,包括急性肾损伤、泌尿系统感染、肾结石等。而Tamm-Horsfall蛋白(THP)于1950年被发现,存在于正常人尿液中,为肾小管髓袢升支及远端小管曲部产生的一种糖蛋白。近年来随着对THP研究的深入,其众多生理功能和广泛应用受到许多研究者的关注,人们发现THP与肾脏疾病有密切联系。因此,深入研究THP在各类肾脏疾病中的作用及机制,可为肾脏疾病的预防、诊断及治疗提供参考。Kidney disease is a common disease,including acute kidney injury,urinary tract infection,and kidney stones etc.The Tamm-Horsfall protein(THP)was discovered in 1950 and is a glycoprotein existing in urine of normal people produced in the ascending branch of the medullary loop of the renal tubule and the distal convoluted tubule.In recent years,with the deepening of the study on THP,many researchers have paid attention to its many physiological functions and wide application.THP has been found to be closely related to kidney disease.Therefore,in-depth study on the role and mechanism of THP in various kidney diseases can provide references for the prevention,diagnosis and treatment of kidney diseases.

关 键 词：肾脏疾病 TAMM-HORSFALL蛋白 泌尿系统感染 

分 类 号：R692[医药卫生—泌尿科学]