药物中频导入辅助康复训练对膝骨关节炎患者疼痛程度及膝关节功能的影响  

Effects of mid-frequency introducing of drugs assisted rehabilitation training on pain and knee function in patients with knee osteoarthritis

作　　者：徐嘉路 缪红[2] 胡静 XU Jia-lu;MIU Hong;HU Jing(Department of Pharmacy,Shanghai Ruijin Rehabilitation Hospital,Shanghai 200023,China;Department of Pharmacy,Shanghai Huangpu District Integrated Chinese Medicine and Western Medicine Hospital,Shanghai 200010,China)

机构地区：[1]上海市瑞金康复医院药剂科,上海200023 [2]上海市黄浦区中西医结合医院药剂科,上海200010

出　　处：《临床和实验医学杂志》2020年第9期976-979,共4页Journal of Clinical and Experimental Medicine

基　　金：国家中医药管理局全国中药特色技术人才培训项目[编号:国中医药人教2015(168)号]。

摘　　要：目的研究药物中频导入辅助康复训练对膝骨关节炎(KOA)患者疼痛程度及膝关节功能的影响。方法前瞻性选择2016年1月至2018年12月上海市瑞金康复医院收治的330例KOA患者,采用随机数字表法将患者分为对照组和观察组,每组各165例。对照组患者采用玻璃酸钠注射联合康复训练治疗,观察组患者在对照组的基础上加用中频电药物导入治疗。比较两组患者的疼痛程度[视觉模拟评分法(VAS)]、膝关节功能[Lysholm膝关节功能评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)]、生活质量[健康状况调查简表(SF-36)]和炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白介素-1β(IL-1β)]水平。结果治疗后,两组患者的SF-36评分、Lysholm评分和VAS评分均有所改善,观察组患者的Lysholm评分和SF-36评分分别为(77. 14±9. 26)分和(87. 91±9. 48)分,均高于对照组,VAS评分为(1. 62±0. 35)分,低于对照组,差异具有统计学意义(P <0. 05)。治疗后,两组患者的WOMAC评分均明显下降,观察组患者的疼痛评分、僵硬评分、关节功能评分和WOMAC总分分别为(3. 16±0. 84)分、(2. 03±0. 47)分、(19. 78±3. 26)分和(27. 72±4. 18)分,均低于对照组,差异具有统计学意义(P <0. 05)。治疗后,观察组患者的TNF-α、IL-6和IL-1β水平分别为(11. 26±1. 73) ng/L、(10. 84±1. 85) ng/L和(16. 92±2. 26) ng/L,均低于对照组,差异具有统计学意义(P <0. 05)。结论中频电药物导入联合玻璃酸钠注射及康复训练治疗可以改善KOA患者的膝关节功能,减轻患者的疼痛症状和炎症反应,提高生活质量,值得在临床推广应用。Objective To study the effects of mid-frequency introducing of drugs assisted rehabilitation training on pain and knee function in patients with knee osteoarthritis( KOA). Methods 330 KOA patients treated in Shanghai Ruijin Rehabilitation Hospital from January2016 to December 2018 were prospectively selected. The patients were divided into control group and observation group by random number table,165 cases in each group. The patients in the control group were treated with Sodium hyaluronate injection combined with rehabilitation training.The patients in the observation group were treated with mid-frequency introducing of drugs on the basis of the control group. The pain degree[VAS],knee function[Lysholm knee function score,WOMAC],quality of life[SF-36]and inflammatory factors[TNF-α,IL-6,IL-1β]were compared between the two groups. Results After treatment,the SF-36 score,Lysholm score and VAS score of the two groups were improved. The Lysholm score and SF-36 score of the observation group were respectively( 77. 14 ± 9. 26) scores and( 87. 91 ± 9. 48) scores,higher than those of the control group,and the VAS score was( 1. 62 ± 0. 35) scores,lower than that of the control group,the differences were statistically significant( P < 0. 05). After treatment,the WOMAC scores of the two groups decreased significantly,and the pain,stiffness,joint function and total WOMAC scores of the observation group were respectively( 3. 16 ± 0. 84) scores,( 2. 03 ± 0. 47) scores,( 19. 78 ± 3. 26)scores and( 27. 72 ± 4. 18) scores,lower than those of the control group,the differences were statistically significant( P < 0. 05). After treatment,the levels of TNF-α,IL-6 and IL-1β in the observation group were respectively( 11. 26 ± 1. 73) ng/L,( 10. 84 ± 1. 85) ng/L and( 16. 92 ±2. 26) ng/L,lower than those in the control group,the differences were statistically significant( P <0. 05). Conclusion Mid-frequency introducing of drugs combined with sodium hyaluronate injection and rehabilitation training can improve knee joint fun

关 键 词：膝骨关节炎 玻璃酸钠 中频电药物导入 康复训练 膝关节功能 

分 类 号：R694.3[医药卫生—泌尿科学] R493[医药卫生—外科学]