早期胚胎停育绒毛中Survivin与Bcl-2基因表达的研究  

Study on the expression of Survivin and Bcl-2 in villus of early embryo arrest

作　　者：何君梅[1] 邹晓燕[1] 刘爽[1] 潘雨露[1] 潘丽萍 HE Jun-mei;ZOU Xiao-yan;LIU Shuang(Gynaecology Department,The Fifth People's Hospital of Ji'nan,Ji'nan Shandong 250000,China)

机构地区：[1]济南市第五人民医院妇产科,山东济南250000

出　　处：《临床和实验医学杂志》2020年第9期991-994,共4页Journal of Clinical and Experimental Medicine

基　　金：山东省济南市卫生健康委员会重点支持科技计划项目(编号:2016-1-11)。

摘　　要：目的探讨Survivin及Bcl-2在早期胚胎停育中的临床意义。方法前瞻性研究,采用免疫组化法检测济南市第五人民医院妇科30例正常早期妊娠、27例早期胚胎停育绒毛中Survivin及Bcl-2的表达情况。结果 Survivin在胚胎停育组绒毛中的表达阳性率(51. 85%)低于正常早期妊娠组(93. 33%),差异具有统计学意义(P <0. 01);正常早期妊娠组中,Survivin++表达率、+++表达率均高于胚胎停育组,差异具有统计学意义(P <0. 05)。Bcl-2在胚胎停育组绒毛中的表达阳性率(62. 96%)低于正常早期妊娠组(96. 67%),差异具有统计学意义(P <0. 01)。胚胎停育组绒毛中Bcl-2++表达率低于正常早期妊娠组(P <0. 01)、+++表达率低于正常早期妊娠组(P <0. 05),差异均具有统计学意义。结论 Survivin、Bcl-2在胚胎早期发育过程中起重要作用,两者低表达或缺失可能导致胚胎停育。Objective To investigate the clinical significance of Survivin and Bcl-2 in villus of early embryo arrest. Methods This study is a prospective study. 30 cases of normal early pregnancy and 27 cases of early embryo arrest were collected. The expression of Survivin and Bcl-2 in villus were detected by immunohistochemistry. All cases came from the Gynecology Department of the Fifth People’s Hospital of Jinan.Results The positive rate of Survivin expression in the villus of early embryo arrest( 51. 85%) was lower than that in the normal early pregnancy group( 93. 33%). The difference was statistically significant( P < 0. 01). The rate of Survivin + + expression and + + + expression in normal early pregnancy group were higher than those in early embryo arrest. The difference was statistically significant( P < 0. 05). The positive rate of Bcl-2 expression in the villus of early embryo arrest( 62. 96%) was lower than that in the normal early pregnancy group( 96. 67%). The difference was statistically significant( P < 0. 01). The rate of Bcl-2 + + expression in normal early pregnancy group were higher than those in early embryo arrest. The difference was statistically significant( P < 0. 01). The rate of Bcl-2 + + + expression in normal early pregnancy group were higher than those in early embryo arrest. The difference was statistically significant( P < 0. 05). Conclusion Survivin and Bcl-2 play an important role in the early development of embryos. Low expression or deletion of Survivin and Bcl-2 may lead to early embryo arrest.

关 键 词：早期胚胎停育 SURVIVIN BCL-2 

分 类 号：R714.21[医药卫生—妇产科学]