五水头孢唑林与奥硝唑联用对直肠癌患者术后切口感染的预防及其对病原菌清除的影响  

Influence of Combination by Cefazolin and Ornidazole on Preventing Incision Infection and Clearing Pathogen in Rectal Cancer Patients

作　　者：孙梦喆 SUN Meng-zhe(Oncology surgery,Jiamusi Central Hospital,Jiamusi Heilongjiang 154002,China)

机构地区：[1]佳木斯市中心医院肿瘤外科,黑龙江佳木斯154002

出　　处：《抗感染药学》2020年第4期570-573,共4页Anti-infection Pharmacy

摘　　要：目的:探究五水头孢唑林与奥硝唑联用对直肠癌患者术后切口感染的预防及其对病原菌清除的影响。方法:选取2017年5月—2018年9月间直肠内科收治的直肠癌术后患者80例资料,统计其采用不同药物预防术后感染将其分为对照组和观察组,每组40例;对照组患者给予奥硝唑预防术后感染,观察组患者给予五水头孢唑林钠与奥硝唑预防术后感染;比较两组患者不同药物治疗后的临床疗效和病原清除率差异,以及预防用药前后炎症指标的改善情况。结果:观察组患者预防用药后的总有效率显著高于对照组(90.00%vs 72.50%,P<0.05),病原菌清除率显著高于对照组(P<0.05);观察组患者用药后CRP、TNF-α、IL-6测得值均低对照组(P<0.05)。结论:五水头孢唑林钠与奥硝唑联用于直肠癌患者预防术后切口感染的效果较好,有效清除了病原菌,控制了对炎症指标的影响,提高了术后预防切口感染的效果。Objective:To study the efficacy of combination by cefazolin and ornidazole on preventing postoperative incision infection in rectal cancer patients and its influence on pathogen clearance.Methods:Data of 80 postoperative patients with rectal cancer admitted to the department of rectal medicine from May 2017 to September 2018 were selected,and the patients were divided into control group and observation group with different drugs to prevent postoperative infection,40 cases in each group.Patients in the control group were given ornidazole to prevent postoperative infection,while patients in the observation group were given cefazolin sodium and ornidazole to prevent postoperative infection.The clinical efficacy and pathogen clearance rate of different drugs were compared between the two groups,also comparing the improvement of inflammatory indicators before and after prophylactic treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group(90.00%vs 72.50%)(P<0.05),and the pathogen clearance rate was significantly higher than that of the control group(P<0.05).CRP,TNF-αand IL-6 were all lower in the observation group than in the control group(P<0.05).Conclusion:The combination of cefazolin sodium and ornidazole have a good effect in preventing postoperative incision infection in rectal cancer patients,effectively removing pathogenic bacteria,controlling the effect on inflammatory indicators,and improving the effect of postoperative incision infection prevention.

关 键 词：直肠癌 切口感染 五水头孢唑林钠 奥硝唑 

分 类 号：R969.4[医药卫生—药理学]