壮族药白鹤灵芝萘醌类化学成分及其药理作用研究进展  

Naphthoquinones from Rhinacanthus nasutus and Their Pharmacological Activities

作　　者：蒙田秀[1] 杨力龙 龚志强[1] 梁芳[1] 唐文均 MENG Tian-xiu;YANG Li-long;GONG Zhi-qiang;LIANG Fang;TANG Wen-jun(Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine,Nanning 530222,China;First Affiliated Hospital of Guangxi of University of Traditional Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学赛恩斯新医药学院,南宁530222 [2]广西中医药大学第一附属医院,南宁530023

出　　处：《中国实验方剂学杂志》2020年第10期213-219,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西自然科学基金项目(2018GXNSFBA281033);广西中医药大学自然基金项目(2016MS001);2016年度院级大学生科研训练项目(2016DXS002)。

摘　　要：白鹤灵芝为为爵床科白鹤灵芝属植物白鹤灵芝Rhinacanthus nasutus的干燥全草,作为广西少数民族地区常用的壮药已经有千余年的用药历史,主要用于清热解毒、润肺、降火、杀虫、止痒、平喘祛痰等。现代药理学研究表明白鹤灵芝具有抑菌、抗病毒、免疫调节、抗肿瘤等多种生物活性,具有较高的应用价值。国内外学者从白鹤灵芝中共分离了多种化合物,主要包括白鹤灵芝醌类化合物20个,还包括有机酸、木脂素、生物碱等结构类型化合物,其中白鹤灵芝醌类化合物具有多种生物活性。目前为止,还没有关于白鹤灵芝醌类化学成分及其药理作用的全面系统研究报道,笔者通过查阅、整理国内外近年来有关白鹤灵芝的文献资料,对白鹤灵芝中提取分离的萘醌类化学成分进行梳理和分析,并对其中萘醌类化合物的药理活性进行综述,发现白鹤灵芝及其萘醌类化合物对肿瘤、糖尿病,非酒精性脂肪肝等均有良好的药物开发潜力,可为后续阐明壮药白鹤灵芝药用的药效物质基础和深度利用民族药资源提供重参考依据。Rhinacanthus nasutus is the shrubs of Acanthacesa of Rhinacanthus nasutus.It has been used as traditional Zhuang medicine for thousands of years,with antipyretic and alexipharmic,antibacterial and antiinflammatory,antiasthmatic and expectorant effects.Modern pharmacological studies have shown that R.nasutus has been used for treatment of various diseases,including pneumonia,gastritis and hepatitis.In addition,naphthoquinone esters isolated from this plant exhibits antitumor,antiviral,antifungal,and immunomodulatory activities,with a high application value.Scholars at home and abroad have isolated a variety of compounds from R.nasutus,including 20 naphthoquinones,organic acids,lignans,alkaloids and other structural types of components.Among them,naphthoquinones have a variety of biological activities.Up to now,there are no systematic and comprehensive report on the chemical constituents and pharmacological effects of naphthoquinones.In this review,we summarized the chemical constituents of naphthoquinones with pharmacological activity,finding that R.nasutus and naphthoquinones have a great potential to be developed as a traditional Chinese medicine for tumors,diabetes,nonalcoholic fatty liver,which can provide an important scientific basis for defining the pharmacodynamic basis of the pharmacological activities and a reference for further research and comprehensive utilization of Zhuang medicine of Rhinacanthus nasutus.

关 键 词：白鹤灵芝 萘醌类 药理作用 研究进展 

分 类 号：R284.1[医药卫生—中药学] R917[医药卫生—中医学]