2,2,6,6-四甲基-4-哌啶胺催化胺化法合成工艺改进研究  

Improvement of 2,2,6,6-tetramethyl-4-piperidinamine synthesis via catalytic amination

作　　者：万文静 阮建成[1,2] 唐赟 周少东 钱超[1,2] 陈新志 WAN Wen-jing;RUAN Jian-cheng;TANG Yun;ZHOU Shao-dong;QIAN Chao;CHEN Xin-zhi(Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;Institute of Zhejiang University-Quzhou,Quzhou 324000,China;Xinxiu Chemistry(Yantai)Co.Ltd.,Yantai 264006,China)

机构地区：[1]浙江省化工高效制造技术重点实验室,浙江大学化学工程与生物工程学院,浙江杭州310027 [2]浙江大学衢州研究院,浙江衢州324000 [3]新秀化学(烟台)有限公司,山东烟台264006

出　　处：《高校化学工程学报》2020年第2期457-462,共6页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金(21476194);国家重点研发计划项目(2016YFB0301800)。

摘　　要：以2,2,6,6-四甲基-4-哌啶酮(TAA)为原料,使用催化胺化法合成受阻胺光稳定剂的中间体2,2,6,6-四甲基-4-哌啶胺(TEMP)。通过调整反应体系的pH值,促进中间体亚胺的生成,提高产物选择性,降低反应温度,使得还原胺化可以在较低温度下顺利进行。优化后的反应条件为:体系pH值为12.5左右,加氢反应温度60℃,压力2 MPa。在该条件下,原料转化率100%,四甲基哌啶胺选择性95.2%。结果表明,pH值12.5时最有利于TEMP的生成。2,2,6,6-Tetramethylpiperidinamine as light stabilizer of hindered amines was synthesized via catalytic amination of 2,2,6,6-tetramethylpiperidone. Imine formation was promoted by adjusting reaction system p H, which facilitated the catalytic amination under mild condition. The selectivity of the product was increased. When studied under pH ~12.5, reaction temperature 60 ℃ and pressure 2 MPa, the selectivity of TEMP was up to 95.2%. The result shows that pH = 12.5 is the most favorable condition for the formation of TEMP.

关 键 词：2 2 6 6-四甲基-4-哌啶胺 2 2 6 6-四甲基-4-哌啶酮 亚胺 还原胺化 

分 类 号：TQ253.2[化学工程—有机化工]