呼吸窘迫综合征早产儿血清Clara细胞分泌蛋白水平变化及意义  

Changes and significance of serum Clara cell secretory protein in preterm infants with respiratory distress syndrome

作　　者：张晓荣 戴红霞[2] 魏红艳 冯玉梅 冯小三 黄琳 ZHANG Xiaorong;DAI Hongxia;WEI Hongyan;FENG Yumei;FENG Xiaosan;HUANG Lin(Department of Pediatrics,Zhuhai People′s Hospital,Zhuhai Hospital Affiliated to Jinan University,Zhuhai 519000,Guangdong Province,China;The School of Health Sciences and Sports,Macao Polytechnic Institute,Macao 999078,China)

机构地区：[1]珠海市人民医院儿科,暨南大学附属珠海医院儿科,广东珠海519000 [2]澳门理工学院健康科学及体育高等学校,澳门999078

出　　处：《新乡医学院学报》2020年第4期347-350,共4页Journal of Xinxiang Medical University

基　　金：珠海市科技计划项目(编号:2014D0401990029)。

摘　　要：目的探讨呼吸窘迫综合征(RDS)早产儿血清Clara细胞分泌蛋白(CCSP)水平变化及临床意义。方法选择2013年6月至2015年6月在珠海市人民医院出生的63例早产儿为研究对象,其中有RDS的30例早产儿纳入观察组,无RDS的33例早产儿纳入对照组,分别于出生2 h及第3、7、14天,采用双抗体夹心酶联免疫吸附法测定2组早产儿血清CCSP水平。结果观察组早产儿出生2 h至第7天血清CCSP水平逐渐升高,第7天达峰值,第7~14天维持在相对稳定水平;对照组早产儿出生2 h至第3天血清CCSP水平逐渐升高,第3天达高峰,然后开始下降,第7~14天维持在相对稳定水平。观察组早产儿出生2 h时血清CCSP水平显著低于出生第3、7、14天(t=-2.805、-3.898、-3.580,P<0.05),观察组早产儿出生第3、7、14天时血清CCSP水平比较差异均无统计学意义(t=-1.092、-0.775、0.318,P>0.05)。对照组早产儿出生第3天时血清CCSP水平显著高于出生2 h及第7、14天(t=3.834、2.627、2.818,P<0.05),对照组早产儿出生2 h及第7、14天时血清CCSP水平比较差异均无统计学意义(t=-1.207、1.016、0.191,P>0.05)。观察组早产儿出生2 h和第3天时血清CCSP水平显著低于对照组(t=2.878、2.658,P<0.05),2组早产儿出生第7、14天时血清CCSP水平比较差异无统计学意义(t=0.776、1.146,P>0.05)。结论RDS早产儿血清CCSP水平降低,血清CCSP水平对预测早产儿RDS的发生、发展和转归有一定价值,其可作为早产儿发生RDS的生物标志物。Objective To investigate the changes and clinical significance of serum Clara cell secretory protein(CCSP)in premature infants with respiratory distress syndrome(RDS).Methods A total of 63 preterm infants born in Zhuhai People’s Hospital from June 2013 to June 2015 were selected as the study objects,including 30 preterm infants with RDS in the observation group and 33 preterm infants without RDS in the control group.The serum CCSP level of preterm infants in the two groups was detected by double-antibody sandwich enzyme-linked immunosorbent assay at 2 hours and 3,7,14 days after birth.Results In the observation group,the serum CCSP level of premature infants gradually increased from 2 hours to 7 days after birth,reached the peak value on the 7th day,and remained at a relatively stable level from the 7th to the 14th day.In the control group,the serum CCSP level of premature infants gradually increased from 2 hours to 3 days after birth,reached the peak value on the 3rd day,then began to decrease and maintained at a relatively stable level from the 7th to the 14th day.The serum CCSP level of premature infants at 2 hours after birth was significantly lower than that on the 3rd,7 thand 14th day in the observation group(t=-2.805,-3.898,-3.580;P<0.05).There was no significant difference in serum CCSP level of premature infants in the observation group on the 3rd,7th and 14th day after birth(t=-1.092,-0.775,0.318;P>0.05).The serum CCSP level of premature infants on the 3rd day after birth was significantly higher than that at 2 hours and 7,14 days after birth in the control group(t=3.834,2.627,2.818;P<0.05).There was no significant difference in serum CCSP levels of premature infants at 2 hours and 7,14 days after birth in the control group(t=-1.207,1.016,0.191;P>0.05).The serum CCSP level of premature infants in the observation group was significantly lower than that in the control group at 2 hours and three days after birth(t=2.878,2.658;P<0.05).There was no significant difference in serum CCSP level of premature in

关 键 词：早产儿 呼吸窘迫综合征 CLARA细胞分泌蛋白 

分 类 号：R722.6[医药卫生—儿科]