不同血清低密度脂蛋白胆固醇在冠心病患者中的表达水平及其与冠心病的关系  

Expression of Low-density Lipoprotein in Patients with Coronary Heart Disease and its Relationship with Coronary Heart Disease

作　　者：黄倚文[1] 杨益[1] 蔡淑仪 HUANG Yi-wen;YANG Yi;CAI Shu-yi(Sanshui Hospital,Foshan Traditional Chinese Medicine Hospital,Foshan,Guangdong,528000,China)

机构地区：[1]佛山市中医院三水医院,广东佛山528000

出　　处：《黑龙江医学》2020年第5期638-641,共4页Heilongjiang Medical Journal

基　　金：广东省佛山市科技计划项目(19200010000836)。

摘　　要：目的探究不同血清LDL-C在冠心病患者中的表达水平及其与冠心病的关系。方法选取佛山市中医院三水医院于2015年6月-2017年2月间住院的冠心病患者85例,检测其LDL-C水平,并按照LDL-C水平分为高、低数值两组,高数值组59例,平均LDL-C为(3.62±0.25) mmol/L,低数值组26例,平均LDL-C为(1.81±0.23) mmol/L。对两组患者进行两年的随访,观察两组患者在此期间心血管疾病的发生率是否不同,并与冠心病其他危险因素相比较。结果在随访期间,高水平组有18例再发冠心病事件,发生率为30.5%,低水平组有2例再发冠心病事件,发生率为7.7%,两组发病率差异有统计学意义(P<0.05)。LDL-CapoB、脂蛋白a、TC、D-二聚体成正相关关系,与HDL-C呈负相关关系。通过logistic回归分析并校正一般因素得血清LDL-C和TC为冠心病独立危险因素。结论 LDL-C表达水平与冠心病发病密切相关,只有积极进行降脂治疗才能改善患者的预后。Objective To investigate the expression of serum Low-density Lipoprotein in patients with coronary heart disease and its relationship with coronary heart disease.Methods 85 patients with coronary heart disease from June,2015 to February,2017 were selected and their serum levels of LDL-C were measured. The patients were divided into two groups according to the level of LDL-C,including high and low value group. There were 59 cases in high value group. The mean LDL-C was(3.62±0.25)mmol/L. There were 26 cases in low value group, and the mean LDL-C was(1.81±0.23) mmol/L. Two groups were followed up for 2 years to observe whether the incidence of cardiovascular disease was different between the two groups,and other risk factors of coronary heart disease were compared.Results During the follow-up period,there were 18 cases of recurrent coronary heart disease in high level group(30.5%) and 2 cases of recurrent coronary heart disease in low level group(7.7%). There was significant difference between the two groups(P<0.05). In addition,there was positively correlation with apoB,lipoprotein A,TC and D-dimer,and these was negatively correlated with HDL-C. Serum LDL-C and coronary heart disease were independent risk factors by logistic regression and correction of general factors.Conclusion The level of low-density lipoprotein expression is closely related with the incidence of coronary heart disease,and only aggressive lipid lowering therapy can improve the prognosis of patients.

关 键 词：冠心病 低密度脂蛋白 胆固醇 

分 类 号：R541.4[医药卫生—心血管疾病]