孕康口服液联合盐酸利托君对先兆流产患者的临床症状、血清PIBF及抑制素A的影响  

Effects of Yunkang Oral Liquid combined with ritodrine hydrochloride on clinical symptoms, serum PIBF, and inhibin A in patients with threatened abortion

作　　者：侯爱琴[1] 刘华[1] 魏建勋[2] HOU Aiqin;LIU Hua;WEI Jianxun(Department of Obstetrics Ward 2,Yan'an University Affiliated Hospital,Yan'an 716000,China;Department of Obstetrics Ward 1,Yan'an University Affiliated Hospital,Yan'an 716000,China)

机构地区：[1]延安大学附属医院产科二病区,陕西延安716000 [2]延安大学附属医院产科一病区,陕西延安716000

出　　处：《药物评价研究》2020年第4期720-724,共5页Drug Evaluation Research

基　　金：陕西省卫生计生科研基金项目(2016D076)。

摘　　要：目的探讨孕康口服液联合盐酸利托君对先兆流产患者的临床症状、血清PIBF及抑制素A的影响。方法选择延安大学附属医院于2017年3月-2019年3月收治的142例先兆流产患者作为研究对象,采用信封法将患者随机分为观察组和对照组,每组各71例。对照组患者静脉滴注盐酸利托君注射液,在5%葡萄糖溶液500 mL中加入100 mg盐酸利托君注射液,起始速度5滴/min,根据患者宫缩情况调节滴注速度,最大速度为35滴/min,持续滴注12 h。停止滴注前30 min口服盐酸利托君片,第1天12片/d,每2 h服用1次,1片/次;第2天6片/d,每4 h服用1次,1片/次;第3~10天4片/d,每6 h服用1次,1片/次。且每日服用总剂量不超过12片(120 mg)。观察组在对照组治疗基础上口服孕康口服液,1瓶/次,3次/d。观察两组患者临床症状消失时间、妊娠延长时间;比较两组孕酮、人绒毛膜促性腺激素(HCG)、孕酮诱导封闭因子(PIBF)、血清抑制素A水平以及不良反应发生情况。结果治疗后,观察组腹痛、腰痛、宫缩消失时间和阴道出血停止时间明显缩短,差异具有统计学意义(P<0.05),且观察组患者的妊娠延长时间相比对照组更长(P<0.05)。治疗后,两组患者的血清孕酮、HCG、PIBF及抑制素A水平均明显升高,差异具有统计学意义(P<0.05);且观察组各激素水平及PIBF水平比对照组改善更明显(P<0.05)。治疗过程中,观察组不良反应发生率与对照组相比,差异不具有统计学意义。结论孕康口服液联合盐酸利托君治疗先兆流产临床效果显著,可显著升高孕妇孕酮、HCG、PIBF及抑制素A水平,缩短患者临床症状消失时间和延长患者妊娠时间,且不良反应发生率低,适合在临床推广应用。Objective To investigate the therapeutic effect of Yunkang Oral Liquid combined with ritodrine hydrochloride on patients with threatened abortion and its effect on serum PIBF and inhibin A. Methods Patients(142 cases) with threatened abortion admitted to Yan’an University Affiliated Hospital from March 2017 to March 2019 were selected as subjects. Patients were randomly divided into observation group and control group by envelope method, with 71 cases in each group. In the control group, Ritodrine Hydrochloride injection was injected intravenously, and 100 mg of Ritodrine Hydrochloride injection was added into 500 mL of 5%glucose solution. The initial rate was 5 drops/min, and the infusion rate was adjusted according to the patients’ contractions. The maximum rate was 35 drops/min, and the infusion continued for 12 h. Ritodrine Hydrochloride Tablets were taken orally 30 min before the infusion was stopped, 12 tablets/d on the first day, once every 2 h, 1 tablet/time;on the second day, 6 tablets/d, once every 4 h, 1 tablet/time;Day 3 to 10, 4 tablets/d, once every 6 h, 1 tablet/time. The total daily dose should not exceed 12 tablets(120 mg).Patients in the observation group were po administered with Yunkang Oral Liquid on the basis of control group, 1 bottle/time, three times daily. The disappearance time of clinical symptoms and prolonged pregnancy time in two groups was observed, and the level of progesterone, HCG, serum PIBF, serum inhibin A, and adverse reactions between two groups were compared. Results After treatment, the disappearance time of abdominal pain, backache, uterine contractions, and vaginal bleeding in the observation group were significantly shorter than those in the control group, the difference is statistically significant(P < 0.05). The prolonged pregnancy time in the observation group was significantly longer than that in the control group(P < 0.05). After treatment, serum progesterone, HCG, PIBF, and inhibin A levels in two groups were significantly increased, the difference is statist

关 键 词：孕康口服液 盐酸利托君 先兆流产 孕酮诱导的封闭因子 抑制素A 

分 类 号：R984[医药卫生—药品]