氧化苦参碱对皮肤疾病的药理作用与临床应用研究进展  

Research progress on dermatopharmacology and clinic application of oxymatrine

作　　者：张明发[1] 沈雅琴[1] ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《药物评价研究》2020年第4期790-796,共7页Drug Evaluation Research

摘　　要：氧化苦参碱能抑制疤痕成纤维细胞增殖和胶原合成,并诱导凋亡和基质金属蛋白酶表达。氧化苦参碱能抑制皮肤癌细胞增殖并诱导凋亡,也能抑制表皮角质形成细胞增殖和黑素形成。氧化苦参碱对各种免疫性和非免疫性皮肤炎症均有抗炎作用,临床上已被试用于多种皮肤病的治疗。Oxymatrine inhibits proliferation and collagen synthesis of scar fibroblasts,and induces apoptosis and expression of MMP.Oxymatrine inhibits proliferation and induces apoptosis of skin carcinoma cells,and too inhibits proliferation of epidermic keratinocyte and melanogenesis.Oxymatrine has anti-inflammatory effects against various immune and non-immune dermatitis.In clinic Oxymatrine has been tried on the treatment of various dermatitis.

关 键 词：氧化苦参碱 皮炎 瘢痕 成纤维细胞 角质形成细胞 黑素生成 

分 类 号：R285.5[医药卫生—中药学] R287.6[医药卫生—中医学]