烟用热熔胶中酚类抗氧化剂的测定  

Determination of phenolic antioxidants in hotmelt adhesives for cigarette

作　　者：牛佳佳[1] 张艳芳 李栋[1] 陈宸[1] 余晶晶[1] 叶长文[1] 贺琛[1] 陈连芳[1] 高凤 NIU Jiajia;ZHANG Yanfang;LI Dong;CHEN Chen;YU Jingjing;YE Changwen;HE Chen;CHEN Lianfang;GAO Feng(Zhengzhou Tobacco Research Institute of CNTC,Zhengzhou 450001,China;China Tobacco Hebei Industrial Co.,Ltd.,Shijiazhuang 050051,China;China Tobacco Sichuan Industrial Co.,Ltd.,Chengdu 610066,China)

机构地区：[1]中国烟草总公司郑州烟草研究院,郑州450001 [2]河北中烟工业有限责任公司,石家庄市050051 [3]四川中烟工业有限责任公司,成都市610066

出　　处：《烟草科技》2020年第5期57-62,98,共7页Tobacco Science & Technology

基　　金：国家烟草专卖局资助标准预研项目“烟用胶粘剂安全卫生要求”(2013QB030)。

摘　　要：为快速测定烟用热熔胶中的酚类抗氧化剂,以四氢呋喃为良性溶剂提取、甲醇为不良溶剂沉淀基体物质的前处理条件,结合超高效液相色谱(UPLC)建立了烟用热熔胶中苯酚、特丁基对苯二酚(TBHQ)、丁基羟基茴香醚(BHA)、2,4-二特丁基苯酚、2,6-二特丁基苯酚、2,6-二特丁基-4-甲基苯酚(BHT)、四[β-(3,5-二叔丁基-4-羟基苯基)丙酸]季戊四醇酯(Irganox 1010)和β-(3,5-二叔丁基-4-羟基苯基)丙酸十八碳醇酯(Irganox 1076)8种酚类抗氧化剂的快速测定方法,并利用该方法测定了10个烟用热熔胶样品。结果表明:①方法的回收率为90.9%~103.4%,相对标准偏差(RSD)≤6.7%,检测限为0.008~0.028μg·mL^-1;②烟用热熔胶样品中抗氧化剂以BHT和Irganox 1010为主,未检出苯酚、TBHQ、BHA、Irganox 1076等食品及食品接触材料中常见的抗氧化剂或污染物。该方法简单、快速、准确,适用于烟用热熔胶中酚类抗氧化剂的测定。In order to rapidly determine the phenolic antioxidants in hotmelt adhesives for cigarettes,an ultra-high performance liquid chromatography(UPLC)method using tetrahydrofuran as the extracting solvent and methanol as the precipitating solvent was developed.Eight antioxidants,including phenol,tertiary butylhydroquinone(TBHQ),butyl hydroxyanisd(BHA),2,4-di-tert-butylphenol,2,6-di-tert-butylphenol,butylatedhydroxytoluene(BHT),Irganox 1010 and Irganox 1076 in hotmelt adhesives for cigarettes were targeted with the method.Ten hotmelt adhesive samples were tested with the developed method.The results showed that:1)The recoveries of the method ranged from 90.9%to 103.4%with the repeatability relative standard deviation(RSD)not higher than 6.7%,and the limit of detection from 0.008 to 0.028μg·mL^-1.2)The antioxidants in the hotmelt adhesive for cigarette samples were primarily BHT and Irganox 1010.Antioxidants in common foods and food contact materials or contaminants,such as phenol,TBHQ,BHA and Irganox 1076,were not detected.This method is simple,rapid,accurate and suitable for determining antioxidants in hotmelt adhesives for cigarettes.

关 键 词：烟用热熔胶 抗氧化剂 超高效液相色谱(UPLC) 酚类物质 

分 类 号：TS426[农业科学—烟草工业]