MCM-41介孔二氧化硅/季铵化壳聚糖载烯啶虫胺纳米颗粒的制备及缓释性能  

Preparation and sustained-release performance of nitenpyram@MCM-41 mesoporous silica/HTCC nanoparticles

作　　者：张嘉坤 黄啟良[2] 吴雁[3] ZHANG Jiakun;HUANG Qiliang;WU Yan(Institute of Genetics and Physiology,Hebei Academy of Agriculture and Forestry Sciences,Shijiazhuang 050051,China;Institute of Plant Protection,Beijing 100193,China;National Center for Nanoscience and Technology,Beijing 100190,China)

机构地区：[1]河北省农林科学院遗传生理研究所,石家庄050051 [2]中国农业科学院植物保护研究所,北京100193 [3]国家纳米科学中心,北京100190

出　　处：《农药学学报》2020年第2期225-232,共8页Chinese Journal of Pesticide Science

基　　金：国家重点研发计划(2017YFD0200301);河北省农林科学院创新工程(1-07-02).

摘　　要：将MCM-41型介孔二氧化硅分散在烯啶虫胺(nitenpyram)水溶液中,借助超声作用使药物分子分散和进入MCM-41孔道中,利用硅羟基与季铵化壳聚糖(N-(2-羟基)丙基-3-三甲基氯化铵壳聚糖,HTCC)之间的静电作用力和氢键作用力,将HTCC包裹在nitenpyram@MCM-41的表面,从而把药物分子封装在孔道内,以减缓药物释放速率。利用扫描电子显微镜(SEM)、氮气吸附-脱附、透射扫描电子显微镜(TEM)、X射线衍射(XRD)、动态光散射激光粒度仪(DLS)和傅里叶红外光谱(FTIR)等对MCM-41和nitenpyram@MCM-41/HTCC纳米颗粒的结构、形貌和Zeta电位等参数进行了表征,考察了nitenpyram@MCM-41/HTCC对烯啶虫胺的载药量和缓释性能。结果表明:HTCC能够很好地结合在nitenpyram@MCM-41表面,形成nitenpyram@MCM-41/HTCC纳米颗粒的外壳,载药量最大为2.8%,有良好的缓释性能。MCM-41 mesoporous silica was dispersed in nitenpyram aqueous solution.With further sonication,nitenpyram was absorbed and entered into the pores of MCM-41 MSNs.The efficient positively charged polymer a quaternized chitosan,(N-(2-hydroxyl)propyl-3-trimethylammonium chitosan chloride,HTCC)coating was realized by the electrostatic interaction and hydrogen bonding between the silicon-hydroxyl groups on the silica nanoparticles and the HTCC.For the shell of HTCC,nitenpyram was encapsulated inside the pores of MSNs.So that a slow and sustained release was realized.The structures,morphologies and Zeta potential,etc.of MCM-41 MSNs and nitenpyram@MCM-41/HTCC nanoparticles were systematically studied using scanning electron microscopy(SEM),N2 adsorption-desorption,transmission electron microscopy(TEM),X-ray diffraction assay(XRD),dynamic light scattering particle size analysis(DLS)and fourier transform infrared spectroscopy(FTIR).The adsorption capacity and release property of nitenpyram@MCM-41/HTCC nanoparticles were also evaluated.The results showed that,HTCC,successfully wrapped on the surface of nitenpyram@MCM-41 nanoparticles,was served as the shell of nitenpyram@MCM-41/HTCC nanoparticles.The loading content was 2.8%,and the novel nitenpyram@MCM-41/HTCC nanoparticles have good sustainedrelease performance.

关 键 词：MCM-41介孔二氧化硅 季铵化壳聚糖 烯啶虫胺 纳米颗粒 缓释性能 

分 类 号：TQ450.68[化学工程—农药化工]