呼吸道合胞病毒感染婴幼儿潮气呼吸肺功能的变化  

Changes in tidal breath pulmonary function of infants with respiratory syncytial virus infection

作　　者：马克 黄尧 王开梅[1] MA Ke;HUANG Yao;WANG Kai⁃mei(Haikou Maternal and Child Health Hospital,Haikou,Hainan 570203,China)

机构地区：[1]海口市妇幼保健院儿科,海南海口570203

出　　处：《热带医学杂志》2020年第3期395-399,共5页Journal of Tropical Medicine

摘　　要：目的探讨呼吸道合胞病毒(RSV)感染婴幼儿水平及潮气呼吸肺功能的变化。方法回顾性分析2016年9月至2018年10月海口市妇幼保健院收治的124例RSV感染婴幼儿以及同期在本院进行体检的100名健康婴幼儿的临床资料,将124例RSV感染婴幼儿纳入观察组,100名健康婴幼儿纳入正常对照组,比较观察组急性期与恢复期和正常对照组呼出气一氧化氮(FeNO)水平、潮气呼吸肺功能、动脉血氧分压(PaO2)和二氧化碳分压(PaCO2)、可溶性白细胞介素-2受体(sIL-2R)水平以及T淋巴细胞亚群相关指标。结果观察组急性期呼吸频率(RR)、呼气峰流速(PTEF)、呼气峰流速/呼气达峰时间(PTEF/TPTEF)、呼气峰流速/潮气量(PTEF/VE)、平均吸气流速(MI)、PaCO2、FeNO高于恢复期以及正常对照组,每公斤潮气量(VT/kg)、吸呼时间比(TI/TE)、呼气达峰时间(TPTEF)、到达峰流速时间/呼气时间(TPTEF/TE)、达峰容积比(%VPF)、呼气达峰容积(VPTEF)、剩余25%潮气量时的呼气流速(TEF25%)、剩余25%潮气量时的呼气流速/呼气峰流速(25/PF)、平均呼气流速(ME)、平均呼气流速/平均吸气流速比(ME/MI)、PaO2低于恢复期以及正常对照组,差异均有统计学意义(P<0.05)。观察组恢复期PTEF/TPTEF、FeNO高于正常对照组,TPTEF/TE、%VPF、25/PF低于正常对照组,差异均有统计学意义(P<0.05)。观察组急性期分化簇3(CD3^+)、分化簇4(CD4^+)、分化簇8(CD8^+)水平低于恢复期以及正常对照组,sIL-2R水平高于恢复期以及正常对照组,差异均有统计学意义(P<0.05);观察组恢复期CD4^+、CD^8+水平低于正常对照组,sIL-2R水平高于正常对照组,差异均有统计学意义(P<0.05)。结论分析RSV感染婴幼儿FeNO水平、潮气呼吸肺功能变化、PaO2和PaCO2以及相关免疫细胞因子水平可有效监测RSV感染婴幼儿病程及预后情况。Objective To explore the changes in tidal breath pulmonary function of infants with respiratory syncytial virus(RSV)infection.Methods A retrospective analysis was performed on clinical data of 124 RSV infection infants who were admitted to the hospital from September 2016 to October 2018 and 100 healthy infants who were examined in the hospital during the same period.The 124 RSV infection infants were included in observation group,while 100 healthy infants were included in normal control group.The fractional exhaled nitric oxide(FeNO)level,tidal breath pulmonary function,arterial blood oxygen partial pressure(PaO2),partial pressure of carbon dioxide(PaCO2),soluble interleukin-2 receptor(sIL-2 R)level and T lymphocyte subsets related indexes in acute phase and the recovery phase were compared between the two groups.Results The respiratory rate(RR),peak tidal expiratory flow(PTEF),PTEF/time to peak tidal expiratory flow(PTEF/TPTEF),PTEF/tidal volume(PTEF/VE),mean inspiratory flow(MI),PaCO2 and FeNO in observation group during acute phase were higher than those during recovery phase and in normal control group,while tidal volume per gram(VT/kg),ratio of respiratory to time(TI/TE),TPTEF,TPTEF/expiratory duration(TPTEF/TE),peak volume ratio(%VPF),volume to peak tidal expiratory flow(VPTEF),expiratory flow with 25%tidal volume(TEF 25%),expiratory flow/expiratory peak flow with 25%tidal volume(25/PF),mean expiratory flow(ME),ME/mean inspiratory flow ratio(ME/MI)and PaO2 significantly lower than those during recovery phase and in normal control group(P<0.05).PTEF/TPTEF and FeNO in observation group during recovery phase were significantly higher than those in normal control group,while TPTEF/TE,%VPF and 25/PF were significantly lower than those in normal control group(P<0.05).The levels of differentiation cluster 3(CD3+),differentiation cluster 4(CD4+)and differentiation cluster 8(CD8+)in observation group during acute phase were significantly lower than those during recovery period and in normal control group(P<0.05),wh

关 键 词：呼吸道合胞病毒 一氧化氮 肺功能 T淋巴细胞亚群 

分 类 号：R511[医药卫生—内科学]