经阴道彩色多普勒超声联合血清E2、β-HCG早期预测妊娠结局价值研究  

Analysis of value of transvaginal color Doppler ultrasound combined with serum E2 andβ-HCG in the early prediction of pregnancy outcomes

作　　者：李柯狄[1] LI Kedi(Department of Ultrasound,Xindu District People’s Hospital,Chengdu,Chengdu 610500)

机构地区：[1]成都市新都区人民医院超声科,成都610500

出　　处：《陕西医学杂志》2020年第6期732-735,共4页Shaanxi Medical Journal

基　　金：四川省卫生和计划生育委员会科研课题(2014JM02255)。

摘　　要：目的:探讨经阴道彩色多普勒超声联合血清雌二醇(E2)、人绒毛膜促性腺激素(β-HCG)早期预测妊娠结局价值。方法:收集早期妊娠女性240例,按妊娠结局将其分为正常妊娠组(n=95)、先兆流产组(n=68)和异位妊娠组(n=77)。采用阴道彩色多普勒超声测量子宫内膜厚度,并检测血清E2、β-HCG,比较各组子宫内膜厚度以及血清E2、β-HCG水平,探讨其联合诊断先兆流产、异位妊娠的价值。结果:正常妊娠组子宫内膜厚度明显大于先兆流产组、异位妊娠组(P<0.05),先兆流产组子宫内膜厚度明显大于异位妊娠组(P<0.05);正常妊娠组血清E2、β-HCG水平明显高于先兆流产组、异位妊娠组(P<0.05),先兆流产组血清E2、β-HCG水平明显高于异位妊娠组(P<0.05)。绘制ROC曲线,E2诊断先兆流产、异位妊娠的AUC为0.861、0.898,95%CI为0.799~0.923、0.841~0.954,β-HCG诊断AUC为0.950、0.927,95%CI为0.913~0.988、0.882~0.972,超声诊断AUC为0.878、0.882,95%CI为0.822~0.934、0.827~0.937,联合检测诊断AUC为0.983、0.978,95%CI为0.967~0.998、0.959~0.997,联合检测对先兆流产、异位妊娠诊断价值最高,超声联合血清E2、β-HCG检测对先兆流产、异位妊娠的诊断准确性、敏感度、特异度、阳性预测值、阴性预测值明显高于各指标单独检测。结论:阴道彩色多普勒超声联合血清E2、β-HCG检测可提高对早期先兆流产、异位妊娠的诊断价值,对早期预测妊娠结局有重要意义。Objective:To explore the value of transvaginal color Doppler ultrasound combined with serum estradiol(E2)and human chorionic gonadotropin(β-HCG)in the early prediction of pregnancy outcomes.Methods:A retrospective study was performed on 240 early pregnancy women who were divided into normal pregnancy group(n=95),threatened abortion group(n=68)and ectopic pregnancy group(n=77)according to the pregnancy outcomes.The transvaginal color Doppler ultrasound was used to measure endometrial thickness,and serum E2 andβ-HCG were measured,and the endometrial thickness and levels of serum E2 andβ-HCG were compared among the groups,and the value of combination of the above indexes in diagnosing threatened abortion and ectopic pregnancy was analyzed.Results:The endometrial thickness in normal pregnancy group was significantly higher than that in threatened abortion group and ectopic pregnancy group(P<0.05),and the endometrial thickness in threatened abortion group was significantly higher than that in ectopic pregnancy group(P<0.05).The levels of serum E2 andβ-HCG in normal pregnancy group were significantly higher than those in threatened abortion group and ectopic pregnancy group(P<0.05),and the levels of serum E2 andβ-HCG in threatened abortion group were significantly higher than those in ectopic pregnancy group(P<0.05).ROC curves were drawn,and the AUC of E2 diagnosis of threatened abortion and ectopic pregnancy were 0.861 and 0.898,and 95%CI were 0.799~0.923 and 0.841~0.954,and the AUC ofβ-HCG diagnosis were 0.950 and 0.927,and 95%CI were 0.913~0.988 and 0.882~0.972,and the AUC of ultrasound diagnosis were 0.878 and 0.882,and 95%CI were 0.822~0.934 and 0.827~0.937,and the AUC of combined detection diagnosis were 0.983 and 0.978,and 95%CI were 0.967~0.998 and 0.959~0.997,and the combined detection had the highest diagnostic value on threatened abortion and ectopic pregnancy.The diagnostic accuracy,sensitivity,specificity,positive predictive value and negative predictive value of ultrasound combined withserum E2 and�

关 键 词：经阴道彩色多普勒超声 雌二醇 人绒毛膜促性腺激素 诊断价值 

分 类 号：R445.1[医药卫生—影像医学与核医学]