鼻炎康片联合卢帕他定治疗过敏性鼻炎的临床研究  

Clinical study on Biyankang Tablets combined with lupatadine in treatment of allergic rhinitis

作　　者：陈洪昌[1] 李国疆[1] CHEN Hong-chang;LI Guo-jiang(Department of ENT,Xindu District People's Hospital,Chengdu 610500,China)

机构地区：[1]成都市新都区人民医院耳鼻喉科,四川成都610500

出　　处：《现代药物与临床》2020年第4期752-755,共4页Drugs & Clinic

摘　　要：目的探讨鼻炎康片联合卢帕他定治疗过敏性鼻炎的临床疗效。方法选择2017年2月-2019年3月在成都市新都区人民医院治疗的过敏性鼻炎患者73例,随机分为对照组(36例)和治疗组(37例)。对照组晚饭后口服富马酸卢帕他定片,10 mg/次,1次/d。治疗组在对照组的基础上口服鼻炎康片,4片/次,3次/d。两组患者均治疗14 d。观察两组患者临床疗效,同时比较治疗前后两组患者血清白细胞介素-8(IL-8)、IL-6、IL-4和免疫球蛋白E(IgE)水平,及临床症状改善时间。结果治疗后,对照组临床有效率为72.22%,显著低于治疗组的94.59%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者IL-8、IL-6、IL-4和IgE等指标均显著降低(P<0.05),且治疗组血清因子水平明显比对照组低(P<0.05)。治疗后,治疗组患者临床症状改善时间明显比对照组早(P<0.05)。结论鼻炎康片联合卢帕他定治疗过敏性鼻炎,可明显抑制患者炎症反应,改善临床症状,显著提高治疗效果。Objective To investigate the clinical efficacy of Biyankang Tablets combined with lupatadine in treatment of allergic rhinitis. Methods Patients(73 cases) with allergic rhinitis in Xindu District People’s Hospital from February 2017 to March 2019 were randomly divided into control(36 cases) and treatment(37 cases) groups. Patients in the control group were po administered with Rupatadine Fumarate Tablets after dinner, 10 mg/time, once daily. Patients in the treatment group were po administered with Biyankang Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the serum level of IL-8, IL-6, IL-4, and IgE, and the improvement time of clinical symptom in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 72.22%, which was significantly lower than 94.59% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the serum level of IL-8, IL-6, IL-4, and IgE in two groups was significantly decreased(P < 0.05), and the serum factor level in the treatment group was significantly lower than that in the control group(P < 0.05). After treatment, the improvement time of clinical symptom in the treatment group was significantly earlier than that in the control group(P < 0.05). Conclusion Biyankang Tablets combined with lupatadine in treatment of allergic rhinitis can significantly inhibit the inflammatory reaction, improve clinical symptoms, and significantly improve the treatment effect.

关 键 词：鼻炎康片 富马酸卢帕他定片 过敏性鼻炎 临床疗效 免疫球蛋白E 鼻塞 鼻痒 

分 类 号：R987[医药卫生—药品]