干预前后荆门地区剖宫产围术期抗菌药物的使用合理性分析  

Analysis on rationality of antibiotics in the perioperative period of cesarean section in Jingmen area before and after the intervention

作　　者：屈素君 白娟 牛静 方功 陈章捷 李杨华[1] QU Su-jun;BAI Juan;NIU Jing;FANG Gong;CHRN Zhang-jie;LI Yang-hua(Department of Pharmacy,The First People's Hospital of Jingmen,Jingmen 448000,China)

机构地区：[1]荆门市第一人民医院药剂科,湖北荆门448000

出　　处：《现代药物与临床》2020年第4期788-791,共4页Drugs & Clinic

基　　金：荆门市科学技术研究与开发计划引导项目(2019YDKY060)。

摘　　要：目的探讨干预前后荆门地区剖宫产围术期抗菌药物的使用合理性。方法回顾性调查荆门市二级以上医院2527患者剖宫产围术期抗菌药物的应用情况,按照干预时段分为干预前组(2017年1~12月,1186例患者)与干预后组(2018年1~12月,1341例患者)。对两组剖宫产围术期抗菌药物品种选择、给药时机、用法用量、用药疗程等情况进行对比分析。结果干预后,抗菌药物的使用合理率由72.31%上升到88.95%。对于注射用头孢唑啉、注射用头孢他啶和甲硝唑氯化钠注射液,干预前组均采用2次/d给药方式,干预后组均采用1次/8 h给药方式。干预前预防用药疗程普遍较长,术后用药时间超过72 h者占29.5%,≤24 h者仅占21.8%。干预后,术后用药时间≤24 h者上升至47.9%。结论通过持续性药师干预,荆门地区剖宫产围术期抗菌药物应用的合理性显著改善,干预效果明显。Objective To analyze the rationality of antibiotics in the perioperative period of cesarean section in Jingmen area before and after the intervention.Methods A retrospective investigation was performed on rationality of antibiotics in 2527 patients who had cesarean section in Jingmen second-level hospital or above.According to the time of intervention,the patients were divided into pre-intervention group(control group,1186 cases,between January and December 2017)and post-intervention group(1341 cases,between January and December 2018).Choice of antibiotic species,timing of administration,usage and dose,and course of treatment were analyzed.Results After the intervention,the rational rate of antibiotics was risen from 72.31%to 88.95%.For Cefazolin for Injection,Ceftazidime for Injection,and Metronidazole Sodium Chloride Injection,the dosing frequency were twice daily before the intervention and once/8 h after the intervention.The duration of prophylactic medication was generally long,and the rate of postoperative medication duration above 72 h was 29.5%,while the rate of that≤24 h was only 21.8%before the intervention.After the intervention,the rate of postoperative medication duration≤24 h was increased to 47.9%.Conclusion Rational use of antibiotics during perioperative period of cesarean section in Jingmen area can be significantly improved through continued intervention.

关 键 词：抗菌药物 剖宫产术 干预 围术期 

分 类 号：R978.1[医药卫生—药品]