老年患者关节置换术后谵妄防治药物的研究进展  

Research progress on drugs in prevention and treatment of postoperative delirium after joint replacement in the elderly patients

作　　者：李淑珍 刘陶江 高进[1] LI Shu-zhen;LIU Tao-jiang;GAO Jin(Department of Anesthesiology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;Xizang Military Area Command Motor Transport Second Brigade General Transport First Battalion Health Clinic,Golmud 816000,China)

机构地区：[1]重庆医科大学附属第一医院麻醉科,重庆400010 [2]西藏军区汽车运输第二旅通用运输一营卫生所,青海格尔木816000

出　　处：《现代药物与临床》2020年第4期815-819,共5页Drugs & Clinic

基　　金：卫生部国家临床重点专科建设项目[财社(2011)170号];重庆市医学重点学科项目[渝卫科教(2007)2]。

摘　　要：术后谵妄是一种常见的术后并发症,主要表现为急性起病,注意力不集中,意识水平改变和思维紊乱,常见于老年患者。关节置换术以老年患者为主,手术创伤大,术后谵妄发生率高。目前针对术后谵妄的防治药物主要有右美托咪定、帕瑞昔布钠、抗精神病药物和激素类。对老年患者关节置换术后谵妄的防治药物进行综述,为临床麻醉提供参考。Postoperative delirium is a common postoperative complication with the main manifestations of acute onset, inattention, altered level of consciousness, and disordered thinking, and it is commonly seen in elderly patients. Joint replacement is mainly for elderly patients, but the surgery is traumatic, and postoperative delirium has a high incidence. At present, the main prevention and treatment drugs for postoperative delirium are dexmedetomidine, parecoxib sodium, antipsychotic drugs, and hormones. Drugs in prevention and treatment of postoperative delirium after joint replacement in the elderly patients are reviewed in this paper, to provide reference for clinical anesthesia.

关 键 词：关节置换 术后谵妄 右美托咪定 帕瑞昔布钠 抗精神病药物 激素 

分 类 号：R971[医药卫生—药品]