基于CRITIC法计算权重系数的星点设计-效应面法优化雷公降压颗粒成型工艺的研究  

Optimization of Formation Process for Leigong Antihypertensive Granules by Central Composite Design-Respones Surface Methodology Based on CRITIC Weighted Evaluation

作　　者：兰太进 常明[2,3] 李巧凤 梁维萍 运晨霞 郭宏伟 LAN Tai-jin;CHANG Ming;LI Qiao-feng;LIANG Wei-ping;YUN Chen-xia;GUO Hong-wei(School of Basic Medical Science,Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Key Laboratory of Longevity and Aging-related Disease,Chinese Ministry of Education&Center for Medical Innovation,Guangxi Medical University,Nanning 530021,China;School of Preclinical Medicine,Guangxi Medical University,Nanning 530021,China;College of Pharmaceutical,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西中医药大学基础医学院,广西南宁530200 [2]长寿与老年相关疾病教育部重点实验室&广西医科大学转化医学研究中心,广西南宁530021 [3]广西医科大学基础医学院,广西南宁530021 [4]广西医科大学药学院,广西南宁530021

出　　处：《中药材》2019年第6期1356-1359,共4页Journal of Chinese Medicinal Materials

基　　金：广西科学研究与技术开发计划项目(桂科攻1598013-8);广西一流学科(药学)建设项目(GXFCDP-PS-2018);广西教育厅“药学研究生创新创业教育暨联合培养基地项目”(20170703);广西中医药民族医药传承创新专项课题(GZLC16-26)。

摘　　要：目的:优选雷公降压颗粒的最佳成型工艺。方法:以辅料配比(糊精-甘露醇)、辅料用量、乙醇体积分数为考察因素,以成型率、休止角、溶化时间、吸湿率、脆碎度作为考察指标,CRITIC法分配各指标权重系数,采用星点设计-效应面法优化雷公降压颗粒成型工艺。结果:CRITIC法得出成型率、休止角、溶化时间、吸湿率、脆碎度的权重系数分别为0.1943、0.2065、0.2089、0.1797、0.2106,最佳成型工艺为辅料配比3∶1,辅料用量4倍,乙醇体积分数80%。结论:优选的成型工艺稳定可行,重复性好,可为雷公降压颗粒的生产提供参考。Objective:To optimize the formation process of Leigong antihypertensive granules(LAG).Methods:Taking the ratio of auxiliary materials(dextrin-mannitol),the amount of auxiliary materials and the volume fraction of ethanol as the investigation factors,while taking the molding rate,angle of repose,melting time,hydroscopicity and friability degree as the investigation indexes,CRITIC method distributed the weight coefficient of each index,the central composite design-respones surface methodology was used to optimize the process of LAG.Results:The weighting coefficients of molding rate,angle of repose,melting time,hydroscopicity,friability degree in processed by CRITIC method were 0.1943,0.2065,0.2089,0.1797,0.2106,respectively.The optimum formation process for LAG was as follows:the composing proportion of dextrin-mannitol was 3∶1,excipient proportion was 4∶1 with 80%ethanol as wetting agent.Conclusion:The optimum formation process of LAG is stable,feasible with good repeatability.It can provide reference for the production of LAG.

关 键 词：雷公降压颗粒 成型工艺 星点设计-效应面法 CRITIC法 

分 类 号：R283.6[医药卫生—中药学]