HIV-1 Nef蛋白神经毒性研究进展  

Progress in research on neurotoxicity of HIV-1 Nef protein

作　　者：单晓宇 赵丽[1] Shan Xiaoyu;Zhao Li(Department of Laboratory Science of Sanitary Microbiology,School of Public Health,Shandong University,Key Laboratory of Infectious Disease Prevention and Control,Key Laboratory of the 13th Five-Year University of Shandong Province,Jinan 250012,China)

机构地区：[1]山东大学公共卫生学院卫生微生物检验学系感染性疾病防控重点实验室山东省“十三五”高校重点实验室,济南250012

出　　处：《中华实验和临床病毒学杂志》2019年第6期667-670,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：HIV-1是获得性免疫缺陷综合征(acquired immunodeficiency syndrome, AIDS)的病原体,可侵犯中枢神经系统(central nervous system, CNS),引起一系列神经系统病变,如HIV相关神经认知障碍(HIV-associated neurocognitive disorder,HAND)。Nef(negative factor)蛋白是HIV-1病毒早期蛋白之一,在HIV-1神经致病性中具有重要作用。本文从Nef对血脑屏障(blood-brain barrier,BBB)通透性的影响、对神经元的直接及间接损伤作用3个方面综述了Nef的神经毒性及其机制。Human immunodeficiency virus-1(HIV-1)is the causative agent of acquired immunodeficiency syndrome(AIDS),which can invade the central nervous system and cause a series of neurological disorders such as HIV-associated neurocognitive disorders(HAND).Nef protein is one of the early proteins of HIV-1 virus,it is found that the neurotoxicity of HIV-1 mutant lacking nef gene is less neurotoxic than that of wild strain with nef gene,indicating that Nef protein plays an important role in HIV-1 neuropathogenicity.In this paper,neurotoxicity and mechanism of Nef are reviewed from three aspects,including the effects of Nef on the blood-brain barrier permeability and the direct and indirect damage to neurons.

关 键 词：人免疫缺陷病毒-1 NEF蛋白 神经毒性 血脑屏障 星形胶质细胞 

分 类 号：R373[医药卫生—病原生物学]