一种新型纳米温度及pH计的合成及性质研究  

Synthesis and properties of a novel nano thermo-and pH-meter

作　　者：郭鹤 王金源 李宇[1] 李明雷 李宏平[1] 杨俊佼[2] GUO He;WANG Jinyuan;LI Yu;LI Minglei;LI Hongping;YANG Junjiao(College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou 450001,China;Beijing Key Laboratory of Environmentally Harmful Chemical Analysis,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]郑州大学化学与分子工程学院,河南省郑州市450001 [2]北京化工大学环境有害化学物质分析北京市重点实验室,北京市100029

出　　处：《计算机与应用化学》2019年第6期589-596,共8页Computers and Applied Chemistry

基　　金：国家自然科学资金(21773215,21543009,J1210060);郑州大学大学生创新训练计划(2018)资助项目.

摘　　要：在本工作中,通过RAFT聚合方法合成了一种具有明确结构的荧光纳米温度及pH计PNIPAM(MAh-4)-b-P4VP(PM4P)。其中PNIPAM作为热响应单元,4-(9-(2-(4-羟基苯基)乙炔基)-7,10-二苯基荧蒽-8-基)苯酚(4)则被设计为荧光信号部分。由于PM4P在乙醇水溶液中随温度升高聚集程度下降,导致AIE效应减弱,进而使PM4P在该体系中的荧光强度呈现出随温度升高而单调下降的趋势,在50℃时荧光强度相比15℃时下降了25%。PM4P表现出良好的pH响应性,从pH=2到pH=11,荧光强度增强1.6倍。可以通过改变荧光单元分子的去质子化平衡和PNIPAM链段的溶剂化构型来调控PM4P的荧光强度。此外,PM4P在温度区间15℃~50℃及pH=2~11范围内表现出了良好的温度响应性和可逆性,有望在温控药物缓释领域得到应用。In this work,one fluorescent nanoscale thermo-and pH-meter PNIPAM(MAh-4)-b-P4VP(PM4P)with well-defined structure was synthesized by RAFT polymerization,in which PNIPAM was introduced as a thermo-responsive unit,and 4-(9-(2-(4-hydroxyphenyl)ethynyl)-7,10-diphenylfluoranthen-8-yl)-phenol(4)was designed as pH and fluorescent signaling part.As the aggregation degree of PM4P decreases with temperature rise in aqueous ethanol solution,the aggregation induced emission(AIE)effect is weakened,and the fluorescence(FL)intensity of PM4P shows a monotonously decrease with increasing temperature.The maximum FL intensity in aqueous ethanol solution at 50℃decreased about 25%compared with that at 15℃.PM4P exhibits a good response to pH within a wide pH range of 2~11,and shows a 1.6-fold emission enhancement at pH=11 compared with that at pH=2.The FL intensity of PM4P can be regulated by changing the deprotonation equilibrium of the fluorescent unit 4 and the solvated configuration of the PNIPAM block.In brief,the PM4P exhibits good temperature responses and good reversibility,within temperature range of 15℃~50℃and pH range of 2~11,which is expected to be applied in the field of multi-stimuli controlled drug release.

关 键 词：温度响应 刺激响应型高分子材料 荧光 可逆加成-断裂链转移 PNIPAM-b-P4VP 

分 类 号：O648[理学—物理化学]