穿心莲内酯增溶制剂技术的研究进展  

Research progress on solubilizing pharmaceutical technology of andrographolide

作　　者：刘业茂 王娴 龙家英 谢龙 孙强[2] 李小芳 LIU Ye-mao;WANG Xian;LONG Jia-ying;XIE Long;SUN Qiang;LI Xiao-fang(Huaiyin People's Hospital,Pharmacy Department,Jinan 250000,Shandong;School of Pharmacy,Chengdu Universty of Traditional Chinese Medicine,Key Laboratony of Standardization for Chinese Herbal Medicine,Ministry of Education,National Key Laboratory Breeding Base of Systematic Research,Development and Uilization of Chinese Medicine Resources,Chengdu 611137,Sichuan)

机构地区：[1]山东省济南市槐荫人民医院药剂科,山东济南250000 [2]成都中医药大学药学院,中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验室—省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中药与临床》2019年第5期75-78,F0003,共5页Pharmacy and Clinics of Chinese Materia Medica

基　　金：基于“药效组分-粒子复合”模式纳米复合粒子的制备及其稳态增效机制的研究,2019YFS0113。

摘　　要：穿心莲内酯是中药穿心莲的主要药效成分之一,具有多种药理活性,目前临床上常用于感染性疾病的治疗。然而,穿心莲内酯水溶性不佳,口服生物利用度低,导致其体内分布和累积较少。通过查阅国内外文献,本文就应用于穿心莲内酯增溶的制剂技术进行综述,包括固体分散技术、超微粉碎技术、环糊精包合技术和纳米制剂技术等,为其进一步开发利用提供依据。Andrographolide is a bioactive diterpenoid lactone compound from a traditional medicinal herb Chuanxinlian.Andrographolide has anti-inflammatory,anti-viral,liver-protecting,anti-tumor and other pharmacological effects.It is extensively used for infectious diseases.However,andrographolide has poor water solubility and low bioavailability,which limited its distribution and accumulation in the body after administration.This paper reviews research advance of pharmaceutical technologies which can increase the solubility of andrographolide from home and abroad,including solid dispersion technology,superfine grinding technology,inclusion technology of cyclodextrin and nanotechnology,to provide reference for the development and utilization of Andrographolide.

关 键 词：穿心莲内酯 增溶 研究进展 

分 类 号：R283.1[医药卫生—中药学]