肺动脉高压对扩张型心肌病预后的影响  

Effect of Pulmonary Hypertension on Prognosis of Dilated Cardiomyopathy

作　　者：刘超[1] 曲杰[1] 王明娟[2] 徐倩[2] 范彦芳[2] 周晓慧[2] 单伟超[1] LIU Chao;QU Jie;WANG Mingjuan;XU Qian;FAN Yanfang;ZHOU Xiaohui;SHAN Weichao(The Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China;Chengde Medical University,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院,河北承德067000 [2]承德医学院,河北承德067000

出　　处：《心血管病学进展》2020年第4期424-427,共4页Advances in Cardiovascular Diseases

基　　金：河北省卫生计生委医学科学研究重点课题项目(20181153)。

摘　　要：目的探讨肺动脉高压对扩张型心肌病患者的预后影响。方法连续入选2016年1月-2018年12月在本院住院的扩张型心肌病患者。肺动脉高压定义为最大三尖瓣反流速度>3.0 m/s。随访患者主要终点包括全因死亡、植入型心脏复律除颤器治疗和因心力衰竭住院。结果共入选139例扩张型心肌病患者,基线平均左室射血分数为31%±5%,其中43.88%的患者合并肺动脉高压。中位随访15个月(1~33个月)期间,33. 09%的患者发生主要心血管不良事件。合并肺动脉高压患者发生主要心血管不良事件风险显著增高(HR 2.202,95%CI 1.151~4.213,P<0. 01)。结论在扩张型心肌病患者中,合并肺动脉高压的预后差。Objective To evaluated the long-term prognostic impact of pulmonary hypertension( PH) on dilated cardiomyopathy( DCM) patients. Methods We included all consecutive patients with DCM who had a baseline and follow-up echocardiographic examinations from January 2016 to December 2018. PH was defined as maximal velocity of tricuspid regurgitation( TRVmax) > 3. 0 m/s.Primary outcome was major adverse cardiovascular events( MACE),including all-cause mortality,appropriate ICD therapy and admission for heart failure. Results A total of 139 patients with dilated cardiomyopathy were selected,with an average baseline left ventricular blood score of( 31%±5%),of which 43.88% combined pulmonary hypertension. During the median follow-up of 15( 1 ~ 33) months,33.09% of the patient suffered from MACE. The risk of MACE in patients with combined PH increased significantly( HR 2.202,95%CI 1.151 ~ 4.213,P<0. 01). Conclusion The long-term outcome was worse in DCM patients with PH.

关 键 词：肺动脉高压 扩张型心肌病 随访 预后 

分 类 号：R544.1[医药卫生—心血管疾病] R542.2[医药卫生—内科学]