肾上腺素能受体信号调控巨噬细胞参与疾病微环境的研究进展  

Research advances on adrenergic receptor signaling involved in disease microenvironment through regulation of macrophages

作　　者：王吉菊 李大金[1,2,3] 杜美蓉 WANG Ji-Ju;LI Da-Jin;DU Mei-Rong(Laboratory for Reproductive Immunology,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China;Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission(NPFPC),Shanghai 200032,China;Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院研究所生殖免疫实验室,上海200011 [2]国家人口和计划生育委员会计划生育药具重点实验室,上海200032 [3]上海市女性内分泌相关疾病重点实验室,上海200011

出　　处：《生理学报》2020年第2期227-234,共8页Acta Physiologica Sinica

基　　金：the corresponding author's laboratory was supported by grants from the National Basic Research Program of China(No.2017YFC1001403);the National Natural Science Foundation of China(No.31270969,81571512,and 81501334)。

摘　　要：肾上腺素能受体(adrenergic receptors, ARs)作为神经系统功能调控的关键受体之一,在多种疾病的免疫微环境形成以及疾病进展中扮演重要角色。近年来ARs及其信号对巨噬细胞功能的调控成为研究热点。在不同疾病微环境中,ARs通过对巨噬细胞的分化与发育发挥不同的调节功能,进而影响肿瘤、肥胖、急性损伤与感染性疾病、心力衰竭以及妊娠相关疾病的发生和发展。本文从ARs的分型及激活途径,ARs在巨噬细胞的表达、功能调控及在不同疾病微环境中的作用等方面进行综述,以期为相关疾病的干预和治疗提供新思路。Adrenergic receptor(AR), one of the key receptors for nervous system, plays an important role in the immune microenvironment and the progression of many diseases. In recent years, the regulation of ARs and its signal on macrophages has become a research hotspot. Researchers found that ARs could exert different regulatory functions on macrophages in different microenvironments, which in turn affects occurrence and development of diseases such as tumor, heart failure, obesity, acute injury, infection and pregnancy-related diseases. This review summarizes the expression and functional regulation of ARs on macrophages, and the role of ARs in microenvironment of related diseases, which might provide new ideas for the treatments.

关 键 词：肾上腺素能受体 巨噬细胞 功能调控 疾病微环境 

分 类 号：R339.2[医药卫生—人体生理学]