Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats  

作　　者：Chao Ye Yun Qiu Feng Zhang Ai-Dong Chen Hong Zhou Jue-Jin Wang Qi Chen Yue-Hua Li Yu-Ming Kang Guo-Qing Zhu 

机构地区：[1]Key Laboratory of Targeted Intervention of Cardiovascular Disease,Collaborative Innovation Center of Translational Medicine for Cardiovascular Disease,and Department of Physiology,Nanjing Medical University,Nanjing 211166,China [2]Department of Physiology,Nanjing Medical University,Nanjing 211166,China [3]Department of Physiology and Pathophysiology,Cardiovascular Research Center,Xi’an Jiaotong University School of Medicine,Xi’an 710061,China

出　　处：《Neuroscience Bulletin》2020年第2期143-152,共10页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(31871148,91639105,31571167,and 31571168).

摘　　要：Sympathetic activation and the kidney play critical roles in hypertension and chronic heart failure.The role of the kidney in sympathetic activation is still not well known.In this study,we revealed an excitatory renal reflex(ERR)in rats induced by chemical stimulation of the kidney that regulated sympathetic activity and blood pressure.The ERR was induced by renal infusion of capsaicin,and evaluated by the changes in renal sympathetic outflow,blood pressure,and heart rate.Renal infusion of capsaicin dose-dependently increased the contralateral renal sympathetic nerve activity,mean arterial pressure,and heart rate.Capsaicin in the corticomedullary border had greater effects than in the cortex or medulla.Intravenous infusion of capsaicin had no significant effects.The effects of renal infusion of capsaicin were abolished by ipsilateral renal denervation,but were not affected by bilateral sinoaortic denervation.Renal infusion of capsaicin increased the ipsilateral renal afferent activity.The ERR was also induced by renal infusion of bradykinin,adenosine,and angiotensin II,but not by ATP.Renal infusion of capsaicin increased c-Fos expression in the paraventricular nucleus(PVN)of hypothalamus.Lesion of neurons in the PVN with kainic acid abolished the capsaicin-induced ERR.These findings indicate that chemical stimulation of kidney causes an excitatory reflex,leading to sympathetic activation,pressor response,and accelerated heart rate.The PVN is an important central nucleus in the pathway of the ERR.

关 键 词：Sympathetic activity Blood pressure Renal afferents Renal reflex Paraventricular nucleus 

分 类 号：R54[医药卫生—心血管疾病]