贵州大果木姜子对急性心肌缺血损伤的保护作用  

Protective Effect of Cinnamomum migao in Guizhou on Acute Myocardial Ischemia Injury

作　　者：李亚辉 杨欣 LI Yahui;YANG Xin(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025

出　　处：《中医药信息》2020年第3期4-8,共5页Information on Traditional Chinese Medicine

基　　金：贵州省科技计划项目(黔科合平台人才〔2017〕5735号-11);贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2019-023);贵州省教育厅青年科技人才成长项目(黔教合KY字〔2018〕211);贵州省科技计划项目(黔科合基础〔2019〕1028号)。

摘　　要：目的:研究贵州大果木姜子对急性心肌缺血损伤的保护作用。方法:采用皮下多点注射盐酸异丙肾上腺素建立大鼠心肌缺血模型,测定大果木姜子对大鼠血清中天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)的含量,检测体内总抗氧化能力(T-AOC)、谷胱甘肽(GSH)的含量。病理组织学观察心肌组织的形态结构变化。结果:大果木姜子可显著降低LDH和CK水平(P<0.05),增加体内总抗氧化能力(T-AOC)及谷胱甘肽(GSH)的含量,有效改善心肌组织的病理组织形态。结论:大果木姜子可能通过作用于抗氧化系统起到对急性心肌缺血损伤的保护作用,但是高、中、低剂量没有呈现剂量依赖性,其中以低剂量效果最突出。Objective:To study the protective effect of Cinnamomum migao on acute myocardial ischemia injury.Methods:The model of myocardial ischemia in rats was established by subcutaneous multipoint injection of isopropinephrine hydrochloride.The serum contents of aspartic aminotransferase(AST),lactate dehydrogenase(LDH)and creatine kinase(CK)were determined,and total antioxidant capacity(T-AOC)and GSH content were detected.The pathological changes of cardiac muscle tissue were observed.Results:Cinnamomum migao could significantly reduce the levels of LDH and CK(P<0.05),and it could increase T-AOC and GSH in the body and effectively improve the tissue morphology of myocardial tissue.Conclusion:Cinnamomum migao may have protective effect on acute myocardial ischemia injury through antioxidant system,which did not show dose-dependence,and the low-dose group showed best result.

关 键 词：大果木姜子 急性心肌缺血 抗氧化能力 

分 类 号：R285.5[医药卫生—中药学]