健康体检人群眼压特征与代谢综合征及其组分的相关性研究  

Correlation between intraocular pressure and metabolic syndrome as well as its components in health check-up population

作　　者：帅平[1] 刘玉萍[1] 王林[1] 杨亮亮[1] 余曼[2] SHUAI Ping;LIU Yu-ping;WANG Lin;YANG Liang-liang;YU Man(Health Management Center,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 611731,China;Department of Ophthalmology,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 611731,China)

机构地区：[1]四川省医学科学院·四川省人民医院健康管理中心,四川成都610072 [2]四川省医学科学院·四川省人民医院眼科,四川成都610072

出　　处：《实用医院临床杂志》2020年第3期16-19,共4页Practical Journal of Clinical Medicine

基　　金：中国科学院“西部之光”人才培训项目(2015);四川省科技厅省院省校合作项目(编号:2017JZ0039);四川省干部保健科研项目(编号:川干研2017-205)。

摘　　要：目的探讨健康体检人群的眼压与代谢综合征(MS)及其组分的相关性。方法我院体检中心进行眼科检查且年龄≥20岁的受检者33233例,询问一般情况、吸烟饮酒史、疾病史,检测身高、体重、腰围、血压、血脂、空腹血糖等指标,采用非接触式眼压计测量眼压。参照中国2型糖尿病防治指南(2013年版)标准对全部受检者进行代谢综合征的诊断,选择受检者的右眼眼压用作数据统计和相关性分析。结果体检人群的眼压呈略右偏的近似正态分布,平均眼压为(15.28±2.89)mm Hg,MS患病率15.2%。MS患者的眼压明显高于非患者(t=-15.64,P<0.001),且随着MS患者异常组分个数的增加,眼压逐渐升高(F=84.55,P<0.001)。除女性的高密度脂蛋白胆固醇-C(HDL-C)异常者外,MS各组分异常者的眼压值均高于正常组(均P<0.05)。多因素回归分析结果显示在控制了年龄和性别等混杂因素后,收缩压、腰围、空腹血糖、甘油三酯、HDL-C、吸烟和饮酒与眼压呈正相关关系。结论健康体检人群的眼压与代谢综合征及其各组分存在相关性。应加强对体检人群眼压和青光眼的监测和健康教育,控制心血管代谢相关危险因素,戒烟限酒,倡导健康生活方式,做好眼部健康管理。Objective To investigate the correlation between intraocular pressure and metabolic syndrome(MS)and its components in health check-up population.Methods We selected 33,233 individuals aged 20 years old and over in health check-up program in Sichuan Provincial People’s Hospital.Data of disease history,drinking and smoking habit,height,weight,waist circumference,blood pressure,serum lipids and fasting blood glucose were collected,and the intraocular pressure were measured by non-contact tonometer.All the individuals were defined by the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China(2013).The intraocular pressure of the right eye was used for data analysis.Results The data of intraocular pressure was normal distribution approximately with average value of 15.28±2.89 mm Hg.The prevalence rate of MS was 15.2%.The intraocular pressure of MS patients was significantly higher than that in non-MS patients(t=-15.64,P<0.001).The intraocular pressure was increased along with increasing number of MS components(F=84.55,P<0.001).The pressure in each abnormal MS component group was obviously higher than those with normal MS component group(all P<0.05)except the abnormal HDL-C group in females.After controlling the age and gender,the results of multivariate regression analysis demonstrated that positive correlation was existed between the intraocular pressure and the systolic pressure,waist circumference,TG,HDL-C,smoking and drinking.Conclusion The intraocular pressure is associated with MS and its components in the health check-up population.The screening of intraocular pressure and health education of glaucoma should be strengthened.The health management of eyes should be encouraged by controlling the risk factors of cardiovascular diseases and metabolic diseases.

关 键 词：眼压 代谢综合征 组分 多因素分析 流行病学调查 

分 类 号：R443[医药卫生—诊断学]