液晶叶酸纳米粒的研究进展  

Research progress of liquid crystal folic acid nanoparticles

作　　者：高金龙[1,2] 龚敬捧 刘永明 李宛萍 王奎涛 GAO Jin-long;GONG Jing-peng;LIU Yong-ming;LI Wan-ping;WANG Kui-tao(College of Chemistry and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China;Key Laboratory of Medicinal Molecular Chemistry,Shijiazhuang 050018,China;Shijiazhuang Pharmaceutical Group,Shijiazhuang 050035,China)

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]河北省药用分子化学重点实验室,河北石家庄050018 [3]石药集团,河北石家庄050035

出　　处：《应用化工》2020年第4期1031-1034,共4页Applied Chemical Industry

基　　金：河北省自然科学基金(B2016208054)。

摘　　要：介绍了液晶叶酸的形成过程,液晶叶酸纳米粒的制备及其作为药物载体的研究进展。液晶叶酸纳米粒作为一种新型药物载体,其结构有序,提供了高度的药物包封,可以控制药物释放,具有生物相容性、无毒、不需要额外的靶向配体等优点。对液晶叶酸纳米材料的发展前景进行了展望。The formation process of liquid crystal folic acid,the preparation of liquid crystal folic nanoparticles as well as the research progress of liquid crystal folic as drug carrier were introduced.Liquid crystal folic acid nanoparticle is a kind of new drug carrier,with high drug incorporation provided by its orderly structure,also it can control the release of drug and has the advantages such as biocompatibility,non-toxicity and no need for additional targeting ligands.The development foreground of liquid crystal folic acid nanoparticles was prospected.

关 键 词：叶酸与叶酸受体 液晶叶酸 纳米粒 药物载体 

分 类 号：TQ050.4[化学工程] R944[医药卫生—药剂学]