改良“五步法”阶梯式微创引流技术在重症急性胰腺炎胰腺周围坏死组织感染中的应用研究  

Study on the application of modified“five-step”stepwise minimally invasive drainage technique in the infection of necrotic tissue around the pancreas in severe acute pancreatitis

作　　者：叶荣强[1] 钟鼎文[1] 谢元财[1] 邓小红[1] YE Rongqiang;ZHONG Dingwen;XIE Yuancai;DENG Xiaohong(Department of Hepatobiliary and Pancreatic Surgery,Ganzhou People's Hospital in Jiangxi Province,Ganzhou,341000,China)

机构地区：[1]江西省赣州市人民医院肝胆胰外科,江西赣州341000

出　　处：《中国现代医生》2020年第10期1-3,7,共4页China Modern Doctor

基　　金：江西省重点研发计划项目(20161BBG70026);江西省赣州市指导性科技计划项目(GZ2017ZSF204)。

摘　　要：目的探讨改良“五步法”阶梯式微创引流技术在重症急性胰腺炎并发胰腺周围坏死组织感染中的应用。方法回顾性纳入2018年1月1日~2018年12月31日行常规综合治疗联合改良“五步法”阶梯式微创引流技术治疗的62例重症急性胰腺炎患者的临床资料作为研究对象(研究组),同期纳入行常规综合治疗的重症急性胰腺炎患者62例的临床资料作为对照组,观察两组患者的血清炎症因子、临床疗效。结果治疗前,研究组与对照组血清中内毒素、IL-6、CRP、TNF-α比较,差异无统计学意义(P>0.05);治疗后,研究组血清中内毒素、IL-6、CRP、TNF-α均优于对照组,差异有统计学意义(P<0.05);研究组的治疗总有效率明显高于对照组(P<0.05)。结论改良“五步法”阶梯式微创引流技术治疗重症急性胰腺炎并发胰腺周围坏死组织感染具有较好的疗效,且可抑制炎症反应。Objective To investigate the modified“five-step”stepwise minimally invasive drainage technique in severe acute pancreatitis complicated with infection of necrotic tissue around the pancreas.Methods The clinical data of 62 patients with severe acute pancreatitis who received routine comprehensive treatment combined with the modified“five-step”stepwise minimally invasive drainage technique from January 1,2018 to December 31,2018 were retrospectively included as the study group,and the clinical data of 62 patients with severe acute pancreatitis who received routine comprehensive treatment during the same period were included as the control group.The serum inflammatory factors and clinical efficacy of the two groups were observed.Results Before treatment,endotoxin,IL-6,CRP and TNF-αin serum in the study group and the control group showed no statistical significance(P>0.05);After treatment,endotoxin,IL-6,CRP and TNF-αin serum in the study group were all better than those in the control group,and inter-group differences were statistically significant(P<0.05);Compared with the control group,the total effective rate was significantly improved in the study group(P<0.05).Conclusion The modified“five-step”stepwise minimally invasive drainage technique in the treatment of severe acute pancreatitis complicated with infection of necrotic tissue around the pancreas has good effect,and can inhibit the inflammatory response.

关 键 词：重症急性胰腺炎 胰腺坏死组织感染 阶梯式 引流技术 

分 类 号：R657.51[医药卫生—外科学]